Evidence map›Paper›PMID 40983579›Full record

ArticleBMJ open2025

Patterns and persistence of SARS-CoV-2 seropositivity among college students at Indiana University-Bloomington.

Chen Chen, Molly Rosenberg, Ming Li, Jonathan T Macy, Christina Ludema

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620798 (Longitudinal COVID-19 Antibody Testing in Indiana University Undergraduate Students), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04620798 nacompletednot on this map

Longitudinal COVID-19 Antibody Testing in Indiana University Undergraduate Students

TypeinterventionalSponsorIndiana UniversityRan2020 to 2020Enrolled1,076ConditionsSARS-CoV-2, Serology, StudentsArmsImmediate vs. delayed provision of antibody test results
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen ChenEpidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, USA cc18@iu.edu.ORCID http://orcid.org/0000-0003-0959-6739
Molly RosenbergEpidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID http://orcid.org/0000-0001-6679-6791
Ming LiEpidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, USA.
Jonathan T MacyDepartment of Applied Health Science, Indiana University Bloomington, Bloomington, Indiana, USA.
Christina LudemaEpidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study examined the patterns and persistence of SARS-CoV-2 seropositivity among college students from March to November 2020. Using data from a sample of students at Indiana University, we assessed (1) the duration and seropositivity following reverse transcription-PCR (RT-PCR)-confirmed SARS-CoV-2 infection and (2) persistence of seropositivity over 10 weeks between two laboratory antibody test visits. SETTING, DESIGN AND

participantsThe longitudinal study was conducted at Indiana University from September to November 2020, with two laboratory antibody tests, and included self-reported RT-PCR results before the observational period from as early as 20 March 2020. This 6-9 month period contributes to our understanding of seropositivity dynamics. The study included 172 college students who had previously tested positive for SARS-CoV-2 and measured their seropositivity.

resultsOur results showed a notable decline (66.7%) in antibody positivity over the observed period. Additionally, 12 weeks postinfection, most students with a SARS-CoV-2 infection history (75%) were no longer seropositive.

conclusionsThese findings reveal a nuanced picture of antibody dynamics, highlighting the complex interplay of factors among college students. The study underscores the need for continued research on antibody levels among young adults to better understand the drivers of variations in antibody persistence. TRIAL REGISTRATION NUMBER: #NCT04620798.

Indexed as

Antibodies, ViralCOVID-19StudentsAdolescentAdultCOVID-19 Serological TestingFemaleHumansIndianaLongitudinal StudiesMaleRandomized Controlled Trials as TopicSARS-CoV-2Seroepidemiologic StudiesUniversitiesYoung AdultAntibodies, Viralantibodiescollege studentsdynamicspublic healthSARS-CoV-2

Identifiers

PMID40983579
PMCPMC12458638

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.