Evidence map›Paper›PMID 40983606›Full record

ArticleScientific reports2025

Associations between sleep and the gut microbiome in adults with colorectal cancer and their caregivers.

Jennifer J Barb, Lena J Lee, Ayaan Ahmed, Elisa H Son, Shubhi Nanda, Li Yang, Yuguang Ban, Amanda Ting, Thomas C Tsai, Youngmee Kim

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer J BarbTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA. barbj@nih.gov.
Lena J LeeTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Ayaan AhmedTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Elisa H SonTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Shubhi NandaTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Li YangTranslational Biobehavioral and Health Promotion Branch, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Yuguang BanUniversity of Miami, Coral Gables, FL, USA.
Amanda TingUniversity of Miami, Coral Gables, FL, USA.
Thomas C TsaiUniversity of Miami, Coral Gables, FL, USA.
Youngmee KimUniversity of Miami, Coral Gables, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adults with cancer and their caregivers have elevated levels of sleep disturbances. In this cross-sectional exploratory study, we examined associations between subjective sleep indices and gut microbiome features among patients with colorectal cancer (CRC) and their sleep-partner caregivers. Forty participants (20 patient-caregiver dyads) completed sleep diaries, stool sampling, and dietary intake questionnaires individually. Patients and caregivers had comparable demographics, dietary and sleep indices. However, patients had significantly different beta diversity (p = .005) and alpha diversity (Inverse Simpson: p = .029) as well as 7 more and 6 less differentially abundant taxa compared with their caregivers. Furthermore, only patients categorized with high sleep efficiency (SE) (≥ 85%) also had higher gut microbial diversity (Inv Simpson: p = .019 and Shannon Index: p = .035). Additionally, some oral and gut microbes were differentially abundant in patients between patients with high or low SE scores. Overall, this study highlights a link between sleep health and gut microbiome characteristics in patients with CRC. Further research is warranted to replicate the current findings with a larger sample, which will allow for the identification of pathways linking sleep to gut microbiome and the development of proper psychobehavioral sleep interventions for adults with cancer and their caregivers to ultimately improve their overall well-being.

Indexed as

CaregiversColorectal NeoplasmsGastrointestinal MicrobiomeSleepSleep Wake DisordersAdultAgedCross-Sectional StudiesFecesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesCaregiversColorectal neoplasmsGut microbiomePatient-caregiver dyadSleep disturbance

Identifiers

PMID40983606
PMCPMC12454654

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.