ArticleJournal of Alzheimer's disease : JAD2025
Longitudinal online weekly reports of non-cognitive symptoms and events can differentiate incident mild cognitive impairment from stable cognitively healthy older adults.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Unobtrusive, in-home assessment of older adults' everyday activities and health events: associations with cognitive performance over a brief observation period.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
BackgroundChanges in noncognitive symptoms such as mood, loneliness, pain, and need for assistance may be potential early markers of mild cognitive impairment (MCI) and Alzheimer's disease and related disorders (ADRD) in older adults. These changes can be subtle and fluctuating, and thus easily missed during intermittent clinic visits.ObjectiveTo assess the relationship of changes in self-perceived internal states and needs to the development of cognitive impairment over time.MethodsWeekly online reports of health-related activities and mood in relation to MCI were assessed for up to 2.9 years in older adults participating in the Oregon Life Laboratory, a study using home-based unobtrusive remote sensing of physical, cognitive, behavioral, physiological, and health-related activities.ResultsThe analytic sample included 129 cognitively healthy volunteers followed for a mean of 2.9 ± 1.2 years. Mean age was 83.5 ± 7.8 years, mean education was 15.7 ± 2.7 years, and 76% were female. Twenty-two participants (17%) developed MCI or dementia while 107 remained cognitively healthy. Over time, more of the participants destined to develop MCI reported: (1) loneliness (p = 0.049), (2) low mood (p = 0.08), (3) pain intensity (p = 0.03) and pain interference (p = 0.01), and (4) needing in-home assistance (p = 0.02) than those remaining cognitively healthy. Baseline scores assessing these symptoms were not clinically concerning, predictive of MCI, nor significantly different between groups.ConclusionsLongitudinal home-based online assessment of non-cognitive aspects of function or internal states (loneliness, mood, pain, needing more assistance) can be sensitive early indicators of changes in brain function leading to MCI and ADRD.
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