Evidence map›Paper›PMID 40985037›Full record

ArticleJAMIA open2025

Automating inductive thematic analyses of health content using large language models: a proof-of-concept study using social media data.

JaMor Hairston, Ritvik Ranjan, Sahithi Lakamana, Anthony Spadaro, Selen Bozkurt, Jeanmarie Perrone, Abeed Sarker

Abstract read
In one paragraph

Article in JAMIA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

JaMor HairstonDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, United States.ORCID https://orcid.org/0000-0001-6069-5869
Ritvik RanjanWheeler High School, Marietta, GA 30068, United States.
Sahithi LakamanaDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, United States.
Anthony SpadaroDepartment of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, United States.
Selen BozkurtDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, United States.
Jeanmarie PerroneDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Abeed SarkerDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, United States.ORCID https://orcid.org/0000-0001-7358-544X

Funding

Mining Social Media Big Data for Toxicovigilance: Studying Substance Use via Natural Language Processing and Machine Learning MethodsR01DA057599 · NIDA · EMORY UNIVERSITY · PI Abeed H Sarker · 2022 to 2026
$2.2M
NIDA NIH HHS R01 DA057599
6 · The paper itself

Abstract

Objectives: Large language models (LLMs) face challenges in inductive thematic analysis, a task requiring deep interpretive, domain-specific expertise. We evaluated the feasibility of using LLMs to replicate expert-driven thematic analysis of social media data. Materials and Methods: Using 2 temporally nonintersecting Reddit datasets on xylazine ( Results: On the validation set, GPT-4o with 2-shot prompting performed best (accuracy: 90.9%; F Conclusion: Our findings suggest that few-shot LLM-based approaches can automate thematic analyses, offering a scalable supplement for qualitative research.

Indexed as

large language modelsnatural language processingprompt engineeringpublic healthqualitative analysissocial mediathematic analysis

Identifiers

PMID40985037
PMCPMC12450316

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.