Evidence map›Paper›PMID 40985578›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Design, synthesis, and bioevaluation of pyrazole-containing tubulin polymerisation inhibitors based on conformational constraint strategy.

Zhongqiao Sun, Jiahao Wang, Fengwei Li, Liancheng Huang, Shide Zheng, Qi Guan, Zhaohua Wang, Weige Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongqiao SunSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Jiahao WangSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Fengwei LiSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Liancheng HuangSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Shide ZhengSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
Qi GuanSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.ORCID 0000-0002-5003-8723
Zhaohua WangDepartment of Otorhinolaryngology & Head and Neck Surgery, Dalian Municipal Friendship Hospital, Dalian, China.
Weige ZhangSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.ORCID 0000-0002-4492-3072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on conformational preference of SMART analogues and conformational constraint strategy, two series of new tubulin polymerisation inhibitors (

Indexed as

Antineoplastic AgentsDrug DesignPyrazolesTubulinTubulin ModulatorsApoptosisCell MovementCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular ConformationMolecular Docking SimulationMolecular StructurePolymerizationStructure-Activity RelationshipAntineoplastic AgentsPyrazolesTubulinTubulin Modulatorsanti-migrationanti-tumor activityconformational constraint strategypyrazole derivativeTubulin polymerisation inhibitor

Identifiers

PMID40985578
PMCPMC12459184

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.