Evidence map›Paper›PMID 40986699›Full record

Trial reportDiabetes care2026

The Effect of Midpregnancy Screening for Gestational Diabetes Mellitus on Pregnancy Outcomes: The TESGO Randomized Controlled Trial.

Chun-Heng Kuo, Ming-Wei Lin, Szu-Chieh Chen, I-Weng Yen, Kang-Chih Fan, Chih-Yao Hsu, Chien-Nan Lee, Chin-Hao Chang, Yu-Han Chang, Yi-Yun Tai and 9 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03523143 (The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03523143 naterminatednot on this map

The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes: the TESGO Randomized Trial

TypeinterventionalSponsorNational Taiwan University HospitalRan2018 to 2022Enrolled967ConditionsPregnancy Complications, Gestational Diabetes Mellitus in PregnancyArmsearly screening and intervention, standard screening and intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Chun-Heng KuoGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-7673-3567
Ming-Wei LinDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City, Taiwan.
Szu-Chieh ChenGood Liver Clinic, Taipei, Taiwan.
I-Weng YenDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Kang-Chih FanGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chih-Yao HsuDepartment of Internal Medicine, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan.
Chien-Nan LeeDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Chin-Hao ChangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Han ChangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Yun TaiDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Chin-Ho ChengDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City, Taiwan.
Kuan-Ying HuangDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City, Taiwan.
Wen-Wei HsuDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu City, Taiwan.
Jessica KangDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Jin-Chung ShihDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Hua HoDepartment of Dietetics, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Yi ChenDepartment of Dietetics, National Taiwan University Hospital, Taipei, Taiwan.
Shin-Yu LinDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0002-0753-2793
Hung-Yuan LiDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0001-9644-2855

Funding

Ministry of Health and Welfare, Taiwan MOHW107-TDU-B-211-123002Ministry of Health and Welfare, Taiwan MOHW108-TDU-B-211-133002Ministry of Health and Welfare, Taiwan MOHW110-TDU-B-211-124002Ministry of Health and Welfare, Taiwan MOHW111-TDU-B-211-134002Ministry of Science and Technology, Taiwan MOST 109-2314-B-030-006-MY3The Liver Disease Prevention and Treatment Research Foundation
6 · The paper itself

Abstract

objectiveNewborns delivered by women with gestational diabetes mellitus (GDM) have accelerated intrauterine growth earlier than the current recommended screening period. We aimed to determine whether universal GDM screening using a single oral glucose intolerance test (OGTT) at 18-20 weeks' gestation improves pregnancy outcomes compared with standard screening at 24-28 weeks' gestation. RESEARCH DESIGN AND

methodsWe conducted a dual-center, parallel, randomized controlled trial with a planned interim analysis in singleton pregnant women to compare the effect of midpregnancy screening for GDM at 18-20 weeks' gestation and standard screening at 24-28 weeks' gestation. GDM was universally screened and diagnosed using 75-g OGTTs and the International Association of the Diabetes and Pregnancy Study Groups criteria. The primary outcome was a composite measure of primary cesarean delivery, birth weight >90th percentile, neonatal hypoglycemia, cord serum C-peptide >90th percentile, gestational hypertension, preeclampsia, and birth trauma.

resultsThe trial was stopped early for futility after the interim analysis. Of the 967 women included in the intention-to-treat analysis, the primary outcome was not significantly different between the two groups. Neonatal hypoglycemia was significantly lower and neonatal adiposity in women with GDM was higher in the midpregnancy screening group compared with the standard screening group. Adverse event rates were similar between the two groups.

conclusionsAdvancing universal GDM screening to midpregnancy at 18-20 weeks' gestation may not improve pregnancy outcomes, except for a reduction in neonatal hypoglycemia. Newborns of women diagnosed with GDM through midpregnancy screening had higher neonatal adiposity.

Indexed as

Diabetes, GestationalPregnancy OutcomeAdultBirth WeightFemaleGlucose Tolerance TestHumansInfant, NewbornPregnancy

Identifiers

PMID40986699
PMCPMC12925975

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.