SynthesisJBRA assisted reproduction2025
Biomarker candidates for oocyte and embryo quality assessment in assisted reproduction: A systematic review.
Synthesis in JBRA assisted reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endocrine and Molecular Mechanisms of Oocyte Aging: From Gonadotropin Signaling to Metabolic and Microenvironmental Dysfunction.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In assisted reproductive technologies, a major challenge is the relatively low overall success rate, mainly due to the absence of reliable markers for assessing oocyte and embryo quality. This study focuses on identifying new biomarkers in follicular fluid and granulosa cells to better understand the factors essential for oocyte maturation. We followed the 2020 PRISMA guidelines to review recent studies from PubMed, Scopus, and Embase, dated 2014-2024. Our review included 3062 participants from 29 studies, which identified key biomarkers in follicular fluid, such as melatonin and interleukin-10, and in granulosa cells, including mitochondrial DNA and specific transcriptomic signatures. These studies also highlighted the importance of morphological variables and DNA methylation in oocyte quality assessment. Our findings suggest that oxidative stress evaluation in follicular fluid and transcriptomic analysis of granulosa cells are promising approaches for determining oocyte quality in assisted reproduction. This knowledge has the potential to enhance patient care and optimize treatment outcomes in this field.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.