ArticleNeuron2025
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health.
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Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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Who cites it
23 citing papers in PubMed.
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- A longitudinal resource for mapping interindividual variation in the aging connectome.Scientific data · 2026Article
- AI segmentation requires accounting for brain size to maintain performance on developmental MRI cohorts.bioRxiv : the preprint server for biology · 2026Article
- Validation of five automated structural MRI quality assessment tools against expert ratings.Neuroradiology · 2026Article
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth.Nature communications · 2026Article
- Mapping Individualized Developmental Imbalance in Youth and Its Association with Psychopathology.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mapping developmental patterns of intrinsic timescale.bioRxiv : the preprint server for biology · 2026Article
- Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026Article
- An open, fully-processed data resource for studying mood and sleep variability in the developing brain.Aperture neuro · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Improved Estimation of Correlation Accuracy for Machine Learning Brain-Phenotype Associations.bioRxiv : the preprint server for biology · 2025Article
- On the translational potential of atlases in precision oncology.Translational cancer research · 2025Review
- Calibration of MRI-based reference intervals to new samples.bioRxiv : the preprint server for biology · 2025Article
- An Open, Fully-processed, Longitudinal Data Resource to Study Brain Development and Transdiagnostic Executive Function.bioRxiv : the preprint server for biology · 2025Article
- An open, longitudinal resource for mapping interindividual variation in the aging connectome.medRxiv : the preprint server for health sciences · 2025Article
- Mapping Individual Differences in Intermodal Coupling in Neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
- Multi-voxel pattern analysis for developmental cognitive neuroscientists.Developmental cognitive neuroscience · 2025Review
Corrections and comments
- Update of
Authors and funding
31 authors.
Golia ShafieiPenn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Nathalia B EsperChild Mind Institute, New York, NY, USA.
Mauricio S HoffmannDepartment of Neuropsychiatry, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; National Institute of Developmental Psychiatry & National Center for Innovation and Research in Mental Health, São Paulo, Brazil; Care Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Lei AiChild Mind Institute, New York, NY, USA.
Andrew A ChenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Jon CluceChild Mind Institute, New York, NY, USA.
Sydney CovitzDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Steven GiavasisChild Mind Institute, New York, NY, USA.
Connor LaneChild Mind Institute, New York, NY, USA.
Kahini MehtaDepartment of Neuroscience, Columbia University, New York, NY, USA.
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Taylor SaloPenn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Tinashe M TaperaKhoury College of Computer Sciences, Northeastern University, Boston, MA, USA.
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Stanley ColcombeCenter for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Christos DavatzikosDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Raquel E GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Pedro M PanDepartment of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Andrea P JackowskiDepartment of Psychiatry, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Ariel RokemDepartment of Psychology, University of Washington, Seattle, WA, USA; eScience Institute, University of Washington, Seattle, WA, USA.
Luis A RohdeGraduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Russell T ShinoharaCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA; Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Nim TottenhamDepartment of Psychology, Columbia University, New York, NY, USA.
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Matthew CieslakPenn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA.
Alexandre R FrancoChild Mind Institute, New York, NY, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA; Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Gregory KiarChild Mind Institute, New York, NY, USA.
Giovanni A SalumChild Mind Institute, New York, NY, USA; Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; National Institute of Developmental Psychiatry & National Center for Innovation and Research in Mental Health, São Paulo, Brazil; ADHD Outpatient Program & Developmental Psychiatry Program, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Medical Council UNIFAJ & UNIMAX, São Paulo, Brazil.
Michael P MilhamChild Mind Institute, New York, NY, USA; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA.
Theodore D SatterthwaitePenn Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: sattertt@pennmedicine.upenn.edu.
Funding
Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Michael Peter Milham · 2017 to 2026
$25.3MNeurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7MLongitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9MPersonalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0MInter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9MPrecision mapping of individualized executive networks in youthR37MH125829 · NIMH · UNIVERSITY OF MINNESOTA · PI Damien A Fair, Theodore Satterthwaite · 2021 to 2026
$4.7MHarmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0MThe Neuroimaging Brain Chart Software SuiteU24NS130411 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Christos Davatzikos, Yong Fan · 2023 to 2026
$3.7MReproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5MNIPreps: integrating neuroimaging preprocessing workflows across modalities, populations, and speciesRF1MH121867 · NIMH · STANFORD UNIVERSITY · PI POLDRACK, RUSSELL A, ROKEM, ARIEL SHALOM · 2021 to 2022
$1.6MA Prospective Study of Endophenotypes in At-Risk Youths and Their SiblingsK08MH079364 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI CALKINS, MONICA E · 2007 to 2011
$750kNIBIB NIH HHS R01 EB022573NIMH NIH HHS K08 MH079364NIMH NIH HHS P50 MH109429NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH123550NIMH NIH HHS R37 MH125829NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NIMH NIH HHS RF1 MH121867NINDS NIH HHS U24 NS130411
Abstract
Mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopathology. To this end, we introduce Reproducible Brain Charts (RBC), an open resource that integrates data from 5 large studies of brain development in youth from three continents (N = 6,346). Bifactor models were used to create harmonized psychiatric phenotypes, capturing major dimensions of psychopathology. Following rigorous quality assurance, neuroimaging data were carefully curated and processed using consistent pipelines in a reproducible manner. Initial analyses of RBC emphasize the benefit of careful quality assurance and data harmonization in delineating developmental effects and associations with psychopathology. Critically, all RBC data-including harmonized psychiatric phenotypes, unprocessed images, and fully processed imaging derivatives-are openly shared without a data use agreement via the International Neuroimaging Data-sharing Initiative. Together, RBC facilitates large-scale, reproducible, and generalizable research in developmental and psychiatric neuroscience.
Indexed as
BrainBrain MappingMental DisordersMental HealthAdolescentChildDatabases, FactualFemaleHumansInformation DisseminationMagnetic Resonance ImagingMaleNeuroimagingReproducibility of Resultsdata harmonizationfMRIMRIneurodevelopmentopen sciencepsychopathologyQCquality controlRBCReproducible Brain Chartsreproducible neurosciencestructural MRI
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