Evidence map›Paper›PMID 40987785›Full record

ArticleScientific reports2025

Targeting Acinetobacter baumannii lipase by coniferous species through metabolomics supported approach.

Rania M Kamal, Ali M El-Halawany, Mohamed S Hifnawy, Asmaa M Otify, Walaa G Fahmy, Noha M Elhosseiny, Ahmed S Attia, Basma M Eltanany, Laura Pont, Fernando Benavente and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rania M Kamal *Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. rania.ahmed@pharma.cu.edu.eg.
Ali M El-HalawanyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Mohamed S HifnawyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Asmaa M OtifyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Walaa G FahmyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Noha M ElhosseinyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Ahmed S AttiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Basma M EltananyDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Laura PontDepartment of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA·UB), University of Barcelona, Barcelona, 08028, Spain.
Fernando BenaventeDepartment of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA·UB), University of Barcelona, Barcelona, 08028, Spain.
Inas Y Younis *Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Manal M Sabry *Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The opportunistic pathogen Acinetobacter baumannii is a particularly problematic nosocomial threat worldwide, leading to high morbidity and mortality rates due to its multiple resistance mechanisms, including the production of lipolytic enzymes. Herein, the aerial parts of three coniferous plants, Pinus canariensis C. Sm. (PC), Cupressus lusitanica Mill. (CL), and Cupressus arizonica Greene. (CA), were extracted and fractionated. Among these, the CA extract followed by CL and then PC, exhibited the highest inhibition of bacterial lipase activity, with half-maximal inhibitory concentration (IC

Indexed as

Acinetobacter baumanniiEnzyme InhibitorsLipaseMetabolomicsPlant ExtractsTracheophytaAnti-Bacterial AgentsChromatography, LiquidTandem Mass SpectrometryAnti-Bacterial AgentsEnzyme InhibitorsLipasePlant ExtractsAcinetobacter baumanniiAntivirulenceConiferousCupressuflavoneLipolytic activity inhibition

Identifiers

PMID40987785
PMCPMC12457599

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.