Evidence map›Paper›PMID 40987866›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Therapeutic association and mechanistic exploration of modified Sijunzi Decoction in radiation-induced sinusitis: an integrated retrospective analysis and network pharmacology study.

Haiyun Wang, Jia Peng, Wenjing Liu, Xi Wang, Jinwen Jiang, Luying Huang, Shunlan Wang

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haiyun WangThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Jia PengThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Wenjing LiuThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Xi WangOtorhinolaryngology Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Jinwen JiangThe First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Luying HuangThe First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Shunlan WangOtorhinolaryngology Head and Neck Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China. wangsl0718@163.com.ORCID http://orcid.org/0000-0003-4629-7025

Funding

National Natural Science Foundation of China No. 82071024
6 · The paper itself

Abstract

purposeNasopharyngeal carcinoma (NPC) is highly sensitive to radiotherapy, which, however, may trigger complications such as radiation-induced sinusitis (RIS) to impair patients' quality of life. Modified Sijunzi decoction (SJZD), a traditional Chinese medicine (TCM) formulation, has been revealed to exert therapeutic potential in RIS prevention and management. However, at this stage, we know little about its specific composition and molecular mechanism, which was a focus of our current study.

methodsThis cross-sectional study was conducted on 86 NPC patients treated at our institution between August 2019 and August 2022. This study further assessed the association between TCM use and RIS incidence by using univariate analysis and multivariate logistic regression. Association rule mining and cluster analysis were employed to identify modified SJZD as the core prescription. Network pharmacology analysis was further applied to elucidate its mechanism of action.

resultsUnivariate analysis demonstrated that TCM exposure was associated with reduced RIS prevalence (55.81%) (P = 0.002), and binary logistic regression analysis confirmed TCM use as an independent protective factor against RIS development (P = 0.001, OR = 0.156, 95% CI: 0.050-0.487). Furthermore, cluster analysis and association rule mining indicated that modified SJZD emerged as the core therapeutic prescription. Network pharmacology analysis identified 67 potential molecular targets of modified SJZD in RIS treatment. In addition, KEGG pathway enrichment revealed that modified SJZD exerted its therapeutic effects through multi-target mechanisms, particularly involving pathways in cancer, microRNAs in cancer, the JAK-STAT signaling pathway, and the NF-κB signaling pathway.

conclusionThere is a potential inverse association between TCM use and RIS incidence. Modified SJZD is identified as the core therapeutic formula, which appears to exert its protective effects through multiple bioactive components, diverse molecular targets, and multiple pathways.

Indexed as

Drugs, Chinese HerbalNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRadiation InjuriesSinusitisAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNetwork PharmacologyRetrospective StudiesDrugs, Chinese HerbalModified Sijunzi decoctionMolecular dockingNasopharyngeal carcinomaNetwork pharmacologyRadiation-induced sinusitisRadiation therapy

Identifiers

PMID40987866

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.