Evidence map›Paper›PMID 40988008›Full record

ArticleNutrition journal2025

Association of habitual diet with skeletal muscle composition in a cross-sectional, population-based imaging study.

Susanne Rospleszcz, Theresa Burger, Nuha Shugaa Addin, Lena S Kiefer, Thierno D Diallo, Nina Wawro, Christopher L Schlett, Fabian Bamberg, Annette Peters, Kurt Gedrich and 1 more

Abstract read
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In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susanne RospleszczDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Killianstr 5a, Freiburg, 79106, Germany. susanne.rospleszcz@uniklinik-freiburg.de.
Theresa BurgerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nuha Shugaa AddinChair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Medical Faculty, Ludwig-Maximilians-Universität (LMU), München, Germany.
Lena S KieferDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
Thierno D DialloDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Killianstr 5a, Freiburg, 79106, Germany.
Nina WawroInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christopher L SchlettDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Killianstr 5a, Freiburg, 79106, Germany.
Fabian BambergDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Killianstr 5a, Freiburg, 79106, Germany.
Annette PetersChair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Medical Faculty, Ludwig-Maximilians-Universität (LMU), München, Germany.
Kurt GedrichZIEL - Institute for Food and Health, Research Group Public Health Nutrition, Technical University of Munich, Freising, Germany.
Jakob LinseisenEpidemiology, University of Augsburg, University Hospital Augsburg, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkeletal muscle health influences overall health and functionality. Nutrition is an important contributor to muscle health, however there is insufficient research on the relation between nutrition and muscle composition, i.e. mass and fatty infiltration, on a population-based level.

objectiveWe aimed to investigate the association of habitual dietary intake of energy-providing nutrients (carbohydrates, fat, protein and alcohol) and of essential amino acids with skeletal muscle fat and muscle area derived by magnetic resonance imaging (MRI) in a sample of middle-aged individuals from a population-based cohort.

methodsWe analyzed N = 294 individuals (45% women, mean age 56.5 years) from the KORA-MRI study, Southern Germany. Muscle fat (%) and muscle area (cm

resultsAlcohol intake was associated with increased skeletal muscle fat, particularly in men (β = 0.28%, 95% confidence interval [0.10%,0.45%]; p = 0.002) per percent of total energy intake). Protein intake was tentatively associated with lower muscle fat (β=-0.33% [-0.68%,0.01%]; p = 0.052). Accounting for overall protein and energy, specific essential amino acids were tentatively associated with lower muscle fat, e.g. leucine (β=-0.63%, [-1.27%,0.01%]; p = 0.054).

conclusionIn middle-aged adults, habitual alcohol and protein intake are associated with fatty infiltration of skeletal muscle. Individualized diet adaptations might improve muscle composition and function.

Indexed as

Body CompositionDietFeeding BehaviorMuscle, SkeletalAgedAmino Acids, EssentialCross-Sectional StudiesDietary ProteinsEnergy IntakeFemaleGermanyHumansMagnetic Resonance ImagingMaleMiddle AgedAmino Acids, EssentialDietary ProteinsAdipose tissueHabitual dietary intakeMuscle qualityPopulation-based studySarcopeniaSkeletal muscle

Identifiers

PMID40988008
PMCPMC12455845

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.