Evidence map›Paper›PMID 40988117›Full record

ArticleJournal of cellular and molecular medicine2025

Jianpi-Huogu Prescription Repairs Nontraumatic Osteonecrosis of the Femoral Head by Inhibiting NAMPT/STK11/HMGCR/ACAT1 Axis-Mediated Lipid Production.

Tao Li, Zhaochen Ma, Shuangrong Gao, Chu Zhang, Yan Jia, Huang Feng, Na Lin, Weiheng Chen, Yanqiong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tao LiInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zhaochen MaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Shuangrong GaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Chu ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yan JiaThird Affiliated Hospital of Beijing University of Chinese Medicine; Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligent, Ministry of Education, Beijing, China.
Huang FengSchool of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, China.
Na LinInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Weiheng ChenThird Affiliated Hospital of Beijing University of Chinese Medicine; Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligent, Ministry of Education, Beijing, China.
Yanqiong ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.ORCID 0000-0002-9358-111X

Funding

National Natural Science Foundation of China 82030122National Natural Science Foundation of China 82474548National Postdoctoral Program for Innovative Talents GZC20233128
6 · The paper itself

Abstract

Jianpi-Huogu Prescription (JHP), integrating the classic Chinese herbal formulas Linggui-Zhugan Decoction and Si-Wu Decoction, has shown clinical efficacy in treating early nontraumatic osteonecrosis of the femoral head (NONFH). In this study, 299 chemical constituents of JHP were identified using ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry. Pharmacological evaluations in rats with early NONFH demonstrated that JHP attenuated femoral head pathological changes, improved gait parameters, increased mechanical pain thresholds, reduced serum levels of triglycerides, total cholesterol, low-density lipoprotein, very-low-density lipoprotein, and the TXB₂/6-keto-PGF₁α ratio while elevating high-density lipoprotein, decreased serum inflammatory cytokines (IL-1β, IL-6, TNF-α) and the RANKL/OPG ratio, and restored bone trabecular morphology and reduced the number of bone marrow adipocytes. Mechanistically, through transcriptomic profiling, network calculations and experimental validation, JHP downregulated NMNAT1, NMNAT3, and NAMPT in the femoral head, thereby reducing NAD

Indexed as

Drugs, Chinese HerbalFemur HeadFemur Head NecrosisLipid MetabolismAcetyl-CoA C-AcetyltransferaseAMP-Activated Protein Kinase KinasesAnimalsCytokinesHydroxymethylglutaryl CoA ReductasesLipidsMaleNicotinamide PhosphoribosyltransferaseRatsRats, Sprague-DawleySignal TransductionACAT1 protein, ratAcetyl-CoA C-AcetyltransferaseAMP-Activated Protein Kinase KinasesCytokinesDrugs, Chinese HerbalHydroxymethylglutaryl CoA ReductasesLipidsNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, ratStk11 protein, ratJianpi‐Huogu Prescriptionlipid metabolismNAMPT/STK11/HMGCR/ACAT1 signal axisnontraumatic osteonecrosis of the femoral headtranscriptome‐based network investigation

Identifiers

PMID40988117
PMCPMC12457209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.