ArticleJournal of cellular and molecular medicine2025
USP14 Mediates Molecular Mechanisms Regulating Aortic Valve Stenosis Through Ubiquitination.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- USP14 Mediates Molecular Mechanisms Regulating Aortic Valve Stenosis Through Ubiquitination.Journal of cellular and molecular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The incidence of aortic valve stenosis (AVS) has been increasing in recent years, making it one of the leading causes of cardiovascular-related deaths among the elderly. Clinical samples from 30 AVS patients and 30 controls treated at Tianjin Chest Hospital between 2010 and 2020 were collected. Analyses included immunofluorescence detection, Western blotting (WB), quantitative RT-PCR analysis (qRT-PCR), haematoxylin and eosin (HE) staining and molecular docking experiments of protein-protein interactions. USP14 was found to be highly expressed in AVS tissues, which was validated by immunofluorescence and WB analyses. qRT-PCR results indicated that the mRNA expression levels of USP14 and CDK4 were significantly elevated in AVS tissues. HE staining revealed significant pathological changes in AVS tissues. Molecular docking experiments demonstrated the interaction between USP14 and CDK4, suggesting a potential regulatory mechanism in AVS. USP14 may be involved in the occurrence and development of AVS by regulating cell proliferation, apoptosis and fibrosis processes. It may serve as a therapeutic target for treating AVS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.