ArticleAnnals of medicine2025
Causes of intrauterine fetal death (IUFD) in term singleton pregnancies (2014-2023): a retrospective study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe risk factors of intrauterine fetal death (IUFD) at term remain uncertain. The cause of death is often difficult to accurately define. This study analyzed the clinical characteristics and the causes of stillbirth at a tertiary maternity center over a 10-year period.
methodsA retrospective study included 70 women with unexpected intrauterine fetal death (IUFD) in singleton term pregnancies (2014 - 2023) at Women's Hospital, Zhejiang University School of Medicine. Cases with fetal anomalies or intrapartum death were excluded. Fetal and maternal variables were analyzed to assess the possible causes of death.
resultsThe majority of mothers were aged 21-34 and of normal weight. Most deliveries occurred before or at 38 weeks . Umbilical cord abnormalities were present in 72.9% of cases. Among the causes of IUFD, unknown causes predominated (61.4%,
conclusionThe high proportion of unexplained term stillbirths (61.4%) primarily reflects limited diagnostic investigation, particularly the lack of comprehensive placental pathology. Umbilical cord abnormalities, notably hypercoiling (28.6%), were the most common identifiable cause. Implementing standardized placental examination protocols is critical to elucidate true causes. Monitoring fetal movement remains vital, and enhanced detection of cord abnormalities may aid intervention.
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