Evidence map›Paper›PMID 40988453›Full record

ReviewCancer biology & medicine2025

Research progress and challenges in the treatment of oncogene-addicted non-small cell lung cancer.

Hanyi Li, Xuanguang Li, Tong Li, Fan Ren, Haochuan Yu, Dianxun Fu, Zuoqing Song, Song Xu

Abstract readReview
In one paragraph

Review in Cancer biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanyi Li *Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Xuanguang Li *Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Tong Li *Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Fan RenDepartment of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Haochuan YuDepartment of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Dianxun FuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zuoqing SongDepartment of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
Song XuDepartment of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.ORCID 0000-0001-6153-387X

Funding

National Natural Science Foundation of China 82172776Tianjin Health Research Project TJWJ2023XK005Tianjin Science and Technology Plan Project 24ZXGZSY00010
6 · The paper itself

Abstract

Over the past 2 decades, remarkable advancements in the screening, diagnosis, and treatment of non-small cell lung cancer (NSCLC) have led to improved patient outcomes. For the treatment of NSCLC with actionable gene mutations, tyrosine kinase inhibitors developed against EGFR, ALK, RET, BRAF, ROS1, NTRK, MET, and KRAS, exhibit substantial antitumor activity and have been incorporated into standard treatment regimens. Additionally, numerous novel therapies, including immunotherapy and antibody-drug conjugate therapy, have been found to benefit patients with NSCLC. This review summarizes current advancements in targeted therapy for NSCLC, according to a systematic search of the PubMed database and synthesis of cutting-edge findings presented at the 2024 American Society of Clinical Oncology Annual Meeting and 2024 World Conference on Lung Cancer.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsOncogenesProtein Kinase InhibitorsHumansImmunotherapyMolecular Targeted TherapyMutationProtein Kinase Inhibitorsacquired resistanceactionable gene mutationconsolidation therapyNon-small cell lung cancertyrosine kinase inhibitors

Identifiers

PMID40988453
PMCPMC12624810

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.