Evidence map›Paper›PMID 40988501›Full record

Observational studyJournal of rehabilitation medicine2025

Early cognitive decline in amyotrophic lateral sclerosis and its relation to driving: an observational study.

Tina Taule, Ole-Bjørn Tysnes, Jörg Aßmus, Annbjørg Spilde Morland, Marit Arnevik Renså, Tone Revheim, Synnøve Glesnes, Tiina Rekand

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tina TauleDepartment of Occupational Therapy, Orthopedic Clinic, Haukeland University Hospital, Bergen, Norway; Western Norway University of Applied Sciences, Bergen, Norway. tit@hvl.no.ORCID 0000-0002-9094-347X
Ole-Bjørn TysnesDepartment of Neurology, Neurologic Clinic, Haukeland University Hospital, Bergen, Norway.
Jörg AßmusCentre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
Annbjørg Spilde MorlandDepartment of Occupational Therapy, Orthopedic Clinic, Haukeland University Hospital, Bergen, Norway.
Marit Arnevik RensåDepartment of Neurology, Neurologic Clinic, Haukeland University Hospital, Bergen, Norway.
Tone RevheimDepartment of Occupational Therapy, Orthopedic Clinic, Haukeland University Hospital, Bergen, Norway.
Synnøve GlesnesDepartment of Occupational Therapy, Orthopedic Clinic, Haukeland University Hospital, Bergen, Norway.
Tiina RekandDepartment of Neurology, Neurologic Clinic, Haukeland University Hospital, Bergen, Norway; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether early cognitive function in amyotrophic lateral sclerosis patients predicts future cognitive function and the decision to cease driving.

designObservational study. SUBJECTS: Patients with amyotrophic lateral sclerosis.

methodsSubjects underwent baseline assessments of cognitive function and driving ability within 4 months of diagnosis, with follow-up evaluation conducted 4 months thereafter. Two hypotheses were tested: (H1) cognitive status remains stable between baseline and follow-up, (H2) patients with baseline cognitive impairment cease driving earlier than those without cognitive changes. Data were analysed using t-tests and regression analysis, with visual inspection of the results.

resultsOf 31 subjects tested at baseline, 5 were under 60 years old, 11 were female, 11 were cognitively impaired, and 61% were driving. Over the 4-month period, cognitive function of the subjects (n = 21) did not change significantly. There was no significant association between baseline cognitive function and follow-up driving status.

conclusionEarly cognitive function assessment in amyotrophic lateral sclerosis predicts future cognitive function but not currently the decision to cease driving. Cognitive impairment occurs early in the disease, highlighting the importance of early evaluation and implementation of safety measures related to driving.

Indexed as

Amyotrophic Lateral SclerosisAutomobile DrivingCognitive DysfunctionAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological Tests

Identifiers

PMID40988501
PMCPMC12490105

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.