ReviewCureus2025
Vitamin D Supplementation in Deficiency States and Combined Calcium-Vitamin D Therapy in Diabetes Prevention and Management: A Systematic Review of Clinical Evidence.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D and calcium are necessary for maintaining metabolic and endocrine homeostasis. These micronutrients may be linked to the onset of diabetic mellitus (DM), according to recent research. To examine the impact of vitamin D and calcium supplementation on the prevention and treatment of type 1 DM (T1DM) and type 2 DM (T2DM), the body of existing research is critically assessed in this systematic review. A comprehensive and methodical literature search was conducted across multiple databases, including PubMed, Embase, Scopus, and the Cochrane Library, covering publications up to January 2025, to identify relevant studies assessing the association between vitamin D and/or calcium levels and the risk of diabetes or glycemic control. The review considered various study designs, such as randomized controlled trials (RCTs), prospective and retrospective cohort studies, as well as case-control analyses, to ensure a robust evaluation of the available evidence. From an initial pool of 3,247 publications, 68 studies qualified for final inclusion. Increased level of vitamin D concentrations was constantly linked to a lower risk of developing T2DM across multiple studies. In addition, other clinical studies demonstrated that supplementation of vitamin D resulted in significant improvements in insulin sensitivity and enhanced pancreatic β-cell function, with the most evident benefits in vitamin D-deficient subjects. While calcium alone showed inconsistent effects, combined supplementation yielded modest yet statistically significant improvements in blood glucose regulation. Vitamin D is a proven micronutrient to regulate glucose metabolism and reduce DM risk, especially in deficient populations. Calcium-vitamin D co-supplementation shows an effective agent for diabetes care; however, more in-depth studies are needed to determine how vitamin D alone, calcium alone, and both together regulate glucose metabolism, and to provide clear evidence to diabetes researchers about how these molecular mechanisms work.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.