Evidence map›Paper›PMID 40988938›Full record

ArticleNature reviews bioengineering2024

Brain-computer interfaces for neuropsychiatric disorders.

Lucine L Oganesian, Maryam M Shanechi

Abstract read
In one paragraph

Article in Nature reviews bioengineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Review
  8. Ethics of brain-computer interface in mental healthcare.Frontiers in human neuroscience · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lucine L OganesianMing Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089 USA.
Maryam M ShanechiMing Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089 USA.

Funding

Model-based neural control of brain stimulation for neuropsychiatric disordersR01MH123770 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHANECHI, MARYAM · 2021 to 2025
$3.0M
Novel multimodal neural, physiological, and behavioral sensing and machine learning for mental statesR61MH135407 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Maryam Shanechi · 2024 to 2026
$2.8M
NIMH NIH HHS R01 MH123770NIMH NIH HHS R61 MH135407
6 · The paper itself

Abstract

Neuropsychiatric disorders such as major depression are a leading cause of disability worldwide with standard treatments, including psychotherapy or medication, failing many patients. Deep brain stimulation holds great potential as an alternative therapy for treatment-resistant cases; however, improving the efficacy of stimulation therapy for neuropsychiatric disorders is hindered by the complexity as well as inter- and/or intra-individual variability in symptom manifestations, neural representations and response to therapy. These challenges motivate the development of brain-computer interfaces (BCIs) that can decode a patient's symptom-state from brain activity as feedback to personalize the stimulation therapy in closed loop. Here, we review progress on developing BCIs for neuropsychiatric care, focusing on neural biomarkers for decoding symptom-states, stimulation site selection and closed-loop stimulation strategies. Moreover, we highlight promising data-driven machine learning and system design approaches and provide a roadmap for realizing these BCIs. Finally, we review current limitations, discuss extensions to other treatment modalities, and outline the required scientific and technological advances. These advances can enable next-generation BCIs that provide an alternative therapy for treatment-resistant neuropsychiatric disorders.

Identifiers

PMID40988938
PMCPMC12453833

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.