ArticleInternational journal of reproductive biomedicine2025
Effect of estradiol on in vitro maturation of immature oocytes in cyclophosphamide-induced premature ovarian failure in NMRI mice: An experimental study.
Article in International journal of reproductive biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Premature ovarian failure (POF) is a condition characterized by the loss of ovarian function, leading to infertility. Objective: This study aims to examine how estradiol supplementation impacts the in vitro maturation of immature oocytes in NMRI female mice exhibiting cyclophosphamide-induced POF. Materials and Methods: In this experimental study, 15 female NMRI mice (8-10 wk, 30 Results: Analysis of oocyte maturity stages showed distinct features. Germinal vesicle oocytes' lowest percentage was in control (3.13%), and highest in sham (76.25%) (p Conclusion: Our study showed that using a dose of 1.5 μg/ml estradiol in vitro results in the highest oocyte maturation in the POF condition and contributes to the existing knowledge on POF and provides insights into potential therapeutic interventions aimed at improving fertility outcomes in individuals with POF.
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