ArticleFrontiers in cardiovascular medicine2025
The role of oxidative stress in modulating mortality risk across the hypertension control cascade.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Assessment of Residual Oxidative Stress in Patients with Well-Controlled Hypertension: A Pilot Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: The role of oxidative stress in hypertensive populations has not yet been fully elucidated. This study examines the association between the Oxidative Balance Score (OBS) and all-cause and cardiovascular mortality under different hypertension control cascade outcomes while assessing mediation by low-grade systemic inflammation and multi-organ function. Methods: This cohort study analyzed 1999-2018 NHANES data, with mortality outcomes from the National Death Index (NDI). It encompassed U.S. adults with hypertension. OBS consists of 20 nutrition and lifestyle factors. Low-grade systemic inflammation (NLR, SIRI) and multi-organ function (eGFR, UACR, FIB-4 index, SUA) were examined as potential mediators. Statistical analyses included Kaplan-Meier analysis, Cox models, restricted cubic splines (RCS), subgroup analyses, and mediation analysis. Results: Participants in the highest OBS quartile (Q4) exhibited lower all-cause mortality (HR: 0.72; 95% CI: 0.59-0.88; Conclusions: A higher OBS is associated with lower all-cause and cardiovascular mortality under different hypertension control cascade outcomes, with a more pronounced effect in controlled hypertension. This relationship is partially mediated through systemic inflammation and multi-organ function.
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