ReviewFrontiers in pharmacology2025
Post-translational modifications in sepsis-induced acute kidney injury: mechanisms and perspectives.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of Histone Modifications in Acute Lung Injury: Molecular Mechanisms and Potential of Traditional Chinese Medicine Treatment.Journal of inflammation research · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis-induced acute kidney injury (SA-AKI), a grave clinical issue with a high mortality rate, has impacted millions of individuals worldwide. Sepsis is a syndrome characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection. Post-translational modifications (PTMs) refer to the chemical alterations that proteins undergo after their synthesis is complete. Various types of PTMs, including phosphorylation, methylation, acetylation, lactylation, and ubiquitination, may play a crucial role in the acute kidney injury (AKI) associated with sepsis by modulating protein function, stability, and interactions. This article highlights the advances in understanding the role of PTMs in the pathogenesis of sepsis-induced acute kidney injury (SA-AKI), addressing existing challenges and offering future perspectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.