Evidence map›Paper›PMID 40990004›Full record

ReviewDementia & neuropsychologia2025

Virtual reality in Parkinson's disease: a systematic review and meta-analysis.

João Vitor Andrade Fernandes, Vera Louise Freire de Albuquerque Figueiredo, Afonso Bezerra Oliveira, Isabelle Albuquerque Reis, Gabrielle de Lacerda Dantas Henrique, Estácio Amaro da Silva

Abstract readReview
In one paragraph

Review in Dementia & neuropsychologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Vitor Andrade FernandesUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0000-0002-0619-4796
Vera Louise Freire de Albuquerque FigueiredoUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0009-0006-1092-4647
Afonso Bezerra OliveiraUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0000-0002-1083-1110
Isabelle Albuquerque ReisUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0009-0008-3760-8294
Gabrielle de Lacerda Dantas HenriqueUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0009-0005-3201-0646
Estácio Amaro da SilvaUniversidade Federal da Paraíba, João Pessoa PB, Brazil.ORCID https://orcid.org/0000-0002-8412-6705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) severely affects motor and non-motor functions, leading to dependency and reduced quality of life. Conventional rehabilitation methods often fail to meet patients' diverse needs. Virtual reality (VR) offers an innovative approach by creating immersive, customizable therapeutic environments. Objective: This systematic review and meta-analysis evaluated the efficacy of VR interventions in PD rehabilitation compared to conventional therapies. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic search was conducted across five databases for randomized controlled trials (RCTs) published until November 2023. Inclusion criteria encompassed RCTs comparing VR with other interventions in PD patients. Data on motor and balance outcomes were extracted. Risk of bias was assessed using the RoB 2 tool. Results: Five RCTs, including 199 participants, were analyzed. VR interventions demonstrated significant improvements in the Time Up-to-Go (TUG) test (mean difference: -2.42; 95% confidence interval - 95%CI -3.95 to -0.89; p=0.002), indicating enhanced dynamic balance. However, the Berg Balance Scale (BBS) results favored the control group (mean difference: 3.28; 95%CI 1.92 to 4.65; p<0.00001). Conclusion: VR interventions significantly improve dynamic balance and mobility in PD patients, as evidenced by TUG results. The limited impact on static balance tasks highlights the need for tailored interventions. While VR shows promise as a complementary therapy, challenges such as cost, accessibility, and standardization must be addressed to enhance its clinical utility.

Indexed as

Meta-AnalysisParkinson DiseaseSystematic ReviewVirtual Reality

Identifiers

PMID40990004
PMCPMC12452101

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.