ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
The Mitochondrial Protein RESISTANCE to APHIDS 9 Interacts with S40 to Resist Aphid Infestation by Modulating Reactive Oxygen Species Homeostasis in Maize (Zea mays).
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Achieving High-Density and Stress-Resilient Maize Breeding Via Germplasm Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The Mitochondrial Protein RESISTANCE to APHIDS 9 Interacts with S40 to Resist Aphid Infestation by Modulating Reactive Oxygen Species Homeostasis in Maize (Zea mays).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
As the corn aphid (Rhopalosiphum maidis) poses a major threat to maize (Zea mays) growth, there is much interest in identifying aphid resistance genes. In this study, an aphid-susceptible maize mutant from an ethyl methanesulfonate-mutagenized library is identified that exhibits greater aphid settlement than the wild type. Using the MutMap approach, the causal gene RESISTANCE TO APHIDS 9 (RTA9) is cloned, which encodes a mitochondrion-localized protein from the Domain of Unknown Function 641 family. Overexpressing RTA9 in maize confers significant resistance to aphids without compromising seed yield. It further identifies the senescence regulator S40 as an interactor of RTA9, which negatively regulates the stability of S40. Knockout of S40 enhanced aphid resistance, while its overexpression increased susceptibility. Further analysis demonstrates that the rta9-1 mutant does not exhibit significant enrichment of differentially expressed genes associated with oxidoreductase activity following aphid infestation. By contrast, genes involved in this pathway are significantly enriched in the s40 mutant. Additionally, aphid-induced reactive oxygen species (ROS) levels are markedly lower in rta9-1 than in the wild type but significantly higher in s40. Collectively, the results suggest that the mitochondrial protein RTA9 and its interacting partner S40 regulate resistance to aphid infestation by modulating ROS homeostasis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.