ArticleAnimal models and experimental medicine2025
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The 5% Problem: How the Biomedical Community Responded to the Animal-to-Human Translation Crisis, and the Case for Non-Animal Methods.Animals : an open access journal from MDPI · 2026Review
- The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast.Animal models and experimental medicine · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe Vietnamese swine represents a promising animal model due to its anatomical, physiological, and pathophysiological similarities to humans. Notably, the arrangement of lobes and ducts in the mammary glands is highly comparable to that of humans and is histologically indistinguishable. Leveraging these advantages through the chemical induction of carcinogenesis in this model offers a robust approach to mimic human exposure to carcinogenic compounds.
methodsThis study elaborates on a protocol for developing a representative model of MNU-induced invasive breast carcinoma in three Vietnamese swine, validated histologically and immunologically. It evaluates not only the tissue similarity with humans, but also the development of chemically induced mammary tumors in an immunologically competent animal. Moreover, this study addresses the existing gap in histological knowledge regarding mammary tissue in the porcine model.
resultsOur findings suggest that this model encompasses the full spectrum of cancer. It incorporates the key elements of a tumor microenvironment that enable tumor growth and propagation, such as immune cells, blood vessels, fibroblasts, extracellular matrix, fatty acids, and signaling molecules.
conclusionsThis model offers significant potential to advance the understanding of cancer pathogenesis and facilitate the development of innovative therapeutic strategies by closely replicating human tumor biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.