Evidence map›Paper›PMID 40991709›Full record

ArticleScience advances2025

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements.

Jamie A Abbott, Junhoe Kim, Beiying Liu, Gabriela K Popescu, Eric Gouaux, Farzad Jalali-Yazdi

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The positive allosteric modulator GNE-9278 increases gating, conductance, and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Dynamic control of NMDA receptor CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jamie A AbbottDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY 14203, USA.ORCID 0000-0002-4223-1232
Junhoe KimVollum Institute, Oregon Health and Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0001-5866-9952
Beiying LiuDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY 14203, USA.ORCID 0000-0002-1446-731X
Gabriela K PopescuDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY 14203, USA.ORCID 0000-0003-4658-2002
Eric GouauxVollum Institute, Oregon Health and Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0002-8549-2360
Farzad Jalali-YazdiVollum Institute, Oregon Health and Science University, 3232 SW Research Drive, Portland, OR 97239, USA.ORCID 0000-0002-0291-3482

Funding

3D STRUCTURE/FUNCTION OF LIGAND GATED ION CHANNELSR01NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 1999 to 2024
$6.7M
3D Structure and Function of Ligand-Gated Ion ChannelsR37NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Gouaux · 2009 to 2026
$4.1M
Molecular Physiology of NMDA ReceptorsR35NS132248 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gabriela K Popescu · 2023 to 2026
$2.3M
Elucidating the Structural Mechanism of NMDA Receptor Modulation by Cryo-Electron MicroscopyF32MH115595 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI JALALI-YAZDI, FARZAD · 2017 to 2020
$192k
NIMH NIH HHS F32 MH115595NINDS NIH HHS R01 NS038631NINDS NIH HHS R35 NS132248NINDS NIH HHS R37 NS038631
6 · The paper itself

Abstract

Canonical

Indexed as

Cryoelectron MicroscopyReceptors, N-Methyl-D-AspartateAnimalsHumansIon Channel GatingModels, MolecularProtein ConformationReceptors, N-Methyl-D-Aspartate

Identifiers

PMID40991709
PMCPMC12459464

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.