ArticleKidney international2025
Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.
Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based guidelines for the diagnosis and management of adult-onset IgA vasculitis.Nature reviews. Rheumatology · 2026Guideline
- Clinical, laboratory, and pathological correlates of crescent formation in biopsy-proven pediatric IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Clinical Value of Kidney Immunodeposits and Urinary Complement Activation Fragments in IgAN.Kidney international reports · 2026Article
- Development of IgA nephropathy following risankizumab therapy for psoriatic arthritis: a case report.CEN case reports · 2026Article
- A Pathway to High Quality Clinical Trials in IgA Vasculitis Nephritis: Meeting Proceedings From a Multiprofessional International Collaborative Workshop.Kidney international reports · 2026Article
- Gut microbiota in Henoch-Schönlein purpura: from pathogenesis to therapeutic strategies.Frontiers in immunology · 2026Review
- Cross-phenotype integration of eQTL-based Mendelian randomization and transcriptomics prioritizesFrontiers in immunology · 2026Article
- Layered immune biomarker monitoring in IgA nephropathy: from mucosal IgA dysregulation to precision therapeutic response assessment.Frontiers in medicine · 2026Review
- Autoimmunity in IgA nephropathy.Frontiers in immunology · 2026Review
- Complement proteins associated with circulatory and glomerular IgA-containing immune complexes in patients with IgA nephropathy.Scientific reports · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
introductionIgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN) are considered similar diseases with different spectra of clinical manifestations. Routine immunofluorescence microscopy of kidney-biopsy specimens of patients with IgAN or IgAVN shows glomerular immune-complex deposits with IgA as (co)dominant immunoglobulin and variable staining for IgG. Complement C3 is usually present in both. To assess the relationships of the glomerular immune complexes in IgAN or IgAVN, we determined glomerular C3-IgA, C3-IgG, and IgA-IgG pairwise colocalization and correlated results with severity of kidney injury.
methodsSections of remnant frozen kidney biopsy specimens from patients with IgAN or IgAVN were stained with an IgG Fc-specific nanobody and antibodies specific for C3 or IgA. Staining was assessed by high-resolution confocal microscopy. Pairwise colocalization in immune-complex deposits was determined by imaging software and results were correlated with Oxford classification MEST-C scores.
resultsAll samples had C3, IgA, and IgG in the glomerular immune-complex deposits, predominantly in mesangial areas, with additional peripheral capillary deposits in IgAVN greater than in IgAN. In IgAN, the mean values of the Pearson correlation coefficients were higher for C3-IgA than for C3-IgG or IgA-IgG; in IgAVN they were similar for C3-IgA and IgA-IgG. Furthermore, C3-IgA colocalization was similar in IgAN and IgAVN, whereas colocalizations of C3-IgG and IgA-IgG were higher in IgAVN than IgAN. In IgAN, but not IgAVN samples, greater C3-IgA colocalization was significantly associated with individual histologic features of active glomerular injury: mesangial hypercellularity, endocapillary hypercellularity, and cellular/fibrocellular crescents. Analyses using mixed-model repeated measures revealed a trend for the correlation of the sum of M+E+C scores with a higher degree of each pairwise colocalization in IgAN and IgAVN, reaching significance for C3-IgA in IgAN and IgAVN and for C3-IgG in IgAVN.
conclusionsAlthough immune-complex deposits differ between IgAN and IgAVN, our data support the nephritogenic role of C3-IgA-containing immune complexes in both diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.