ArticleAnnals of medicine2025
Risk factors of diagnosis of and mortality from late onset neonatal sepsis caused by multidrug-resistant organisms - a case-control study at a tertiary Hospital in the UAE.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Risk factors for multidrug resistance and mortality in healthcare-associated neonatal gram-negative bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Neonatal Infections Caused by Multidrug-Resistant Bacteria: An Analysis of Prevalence, Risk Factors, and Therapeutic Implications-A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
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Authors and funding
10 authors.
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Abstract
backgroundNeonatal sepsis caused by multidrug-resistant organisms (MDROs) is a significant cause of morbidity and mortality. Research on MDRO sepsis risk factors in the UAE is limited; hence, proper evaluation for targeted therapy is needed.
objectiveThis study aimed to identify risk factors for MDRO in late-onset neonatal sepsis.
methodsThis case-control study was carried out in NICU of Tawam Hospital, and data from culture-positive LOS patients were collected between January 2015 and February 2019, including Patient demographics, clinical findings, and presence of antibiotic resistance. The cases were those neonates with late-onset sepsis (LOS) due to MDRO, and the controls were those non-MDRO. Antibiotic regimens for LOS management and mortality rates were collected. Chi-square, independent
resultsOf the 172 neonates with LOS episodes (29 cases and 143 controls), 49.0% were female, 82.0% were preterm, the median age was 24 days, IQR (10-75), and the median weight was 1,042.0 g; IQR(700-1860). Extended-spectrum beta-lactamases (45.0%) and cephalosporin-resistant Klebsiella spp. (17.0%) were the most common MDROs in our hospital. The incidence of resistance to empiric antibiotic regimens was 7.0% in the case group and 9.0% in the control group. The independent risk variables for MDRO sepsis were female sex (OR 2.67; 95% CI 1.13-6.25), necrotizing enterocolitis (OR 4.54; 95% CI 1.98-10.4), and the use of umbilical arterial catheters (OR 5.02; 95% CI 1.09-23.11). The overall mortality rates (41.0% vs. 40.0%) and 72-hour mortality rates (17.0% vs. 14.0%) exhibited no significant differences between the MDRO and non-MDRO cohorts.
conclusionThe study identified extended-spectrum beta-lactamase Enterobacteriaceae as the predominant MDRO in the unit. It highlighted several independent risk factors associated with MDRO infections; hence, longer hospital stays, including female sex, NEC, and UAC. These results support the integration of risk-based empirical antibiotic regimens in NICUs.
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