Evidence map›Paper›PMID 40992932›Full record

Observational studyStroke and vascular neurology2026

Macular choriocapillaris perfusion area: a potential biomarker of mild cognitive impairment in patients with cerebral small vessel disease.

Weitao Yu, Zeqi Shen, Weifen Zhang, Mengmeng Yue, Shouxuan Gao, Jiawei Ye, Wanmao Ni, Panpan Shen, Lujie Han, Shunyuan Guo and 6 more

2 registry-linked trialsAbstract readObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke and vascular neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06164262 recruitingnot on this map

Dementia Risk rEgistry for Young And Middle-aged CSVD Patients in the Next 10 Years（DREAM-10）

Typeobservational_patient_registrySponsorZhejiang Provincial People's HospitalRan2024 to 2034Enrolled1,000ConditionsCerebral Small Vessel Diseases, Dementia, Mixed, Health Behavior, Health Behavior, RiskyArmsIndividuals with CSVD
NCT06431711 recruitingnot on this map

Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Disease

TypeobservationalSponsorZhejiang Provincial People's HospitalRan2024 to 2034Enrolled2,400ConditionsCerebral Small Vessel Diseases, Retinal Ischemia, Choroid, Injury
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Weitao YuThe Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0009-4242-1923
Zeqi ShenPostgraduate Training Base Alliance, Wenzhou Medical University (Affiliated People's Hospital), Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0007-2764-2563
Weifen ZhangThe Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0001-9702-5866
Mengmeng YuePostgraduate Training Base Alliance, Wenzhou Medical University (Affiliated People's Hospital), Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0001-0263-7094
Shouxuan GaoCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Jiawei YeSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wanmao NiCancer Center, Department of Pathology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Panpan ShenDepartment of the Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Lujie HanSchool of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shunyuan GuoCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Jie ZhengDepartment of Radiology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Liang YuDepartment of Radiology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Faliang GaoCenter for Rehabilitation Medicine, Department of Neurosurgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0000-0002-8170-2156
Yu GengCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Chaoyang Hong *Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China zhangsheng@hmc.edu.cn hcy1999@sina.com.
Sheng Zhang *Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China zhangsheng@hmc.edu.cn hcy1999@sina.com.ORCID http://orcid.org/0009-0000-7035-9893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop and validate retinal vascular biomarkers for detecting mild cognitive impairment (MCI) in cerebral small vessel disease (CSVD) using swept-source optical coherence tomography angiography (SS-OCTA).

methodsParticipants with MCI and normal cognition were prospectively enrolled from two ongoing cohorts (Dream-10 and FRESH-CSVD; NCT06164262 and NCT06431711). All participants underwent SS-OCTA and structural MRI (S-MRI). Individuals with Alzheimer's disease were excluded based on plasma biomarkers. Participants were split into development (January-August 2024) and temporal validation (September 2024-January 2025) cohorts. Feature selection was conducted using least absolute shrinkage and selection operator regression, followed by receiver operating characteristic analyses.

resultsA total of 209 participants were included, with 48.8% (102/209) diagnosed with MCI. In the development cohort (n=136), the 3-6 mm macular choriocapillaris perfusion area (CCPA) of the left eye (oculus sinister, OS) showed superior diagnostic accuracy for MCI (AUC=0.906), outperforming S-MRI markers (all p

conclusionSS-OCTA-derived macular CCPA, especially in the 3-6 mm OS region, may serve as a promising and non-invasive biomarker for CSVD-related MCI. Further multicentre studies are needed to establish its clinical applicability.

Indexed as

Cerebral Small Vessel DiseasesCerebrovascular CirculationChoroidCognitionCognitive DysfunctionMacula LuteaPerfusion ImagingRetinal VesselsTomography, Optical CoherenceAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCerebrovascular DisordersCognitive Dysfunction

Identifiers

PMID40992932
PMCPMC13347953

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.