ArticleNature immunology2025
A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues.
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Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46citing papers in PubMed, 1 pooled it
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders.Frontiers in immunology · 2025Pooled it
- Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease.Nature immunology · 2026Article
- LCN2-Driven Fibroblast Ferroptosis-Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- "Don't Force the Stem Cell for Hair Regeneration: Rather Electrically and Functionally Prime the Fibroblast."Stem cell reviews and reports · 2026Article
- Single-cell transcriptomics reveals epithelial-stromal crosstalk underlying fibrotic remodeling in frontal fibrosing alopecia.iScience · 2026Article
- Cardiac fibroblast diversity in HFpEF: states, niches, interorgan drivers and targets.Nature reviews. Cardiology · 2026Review
- Beyond fibrosis: Emerging role of IL-11 in regulating innate and adaptive immune cell plasticity.Molecular biology reports · 2026Review
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- IL11+ fibroblasts are implicated in nonresponse to anti-TNF-α via fibrosis in inflammatory bowel disease.JCI insight · 2026Article
- The embryonic origins of site-specific arthritis.Nature immunology · 2026Article
- Spatial Orchestration of Skin Fibrosis by a CD8+ T cell- Myofibroblast Axis.bioRxiv : the preprint server for biology · 2026Article
- Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity.Journal of hematology & oncology · 2026Review
- A stretch-responsive fibroblast program promotes epidermal stem cell self-renewal during skin expansion.Nature communications · 2026Article
- Beyond scarring: a next-generation vision for pulmonary fibrosis management.Molecular biology reports · 2026Review
- A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9Nature immunology · 2026Article
- Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.Nature communications · 2026Article
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Article
- An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.Cell press blue · 2026Article
- A Mouthful of Genomic Data: Single-Cell Insights into Salivary Gland Biology and Disease.Biology · 2026Review
Corrections and comments
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Authors and funding
38 authors.
Lloyd SteeleWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Bayanne OlabiWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Kenny RobertsWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-6155-0821
Pavel V MazinWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-9268-3352
Simon KoplevCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8586-5614
Catherine TudorWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Benjamin RumneyWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Chloe AdmaneWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Treasa JiangSt John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.
Donovan Correa-GallegosInstitute for Stroke and Dementia Research (ISD), University Hospital (Klinikum LMU), Munich, Germany.
Keerthi Priya ChakalaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0009-0008-1071-8629
Aljes BinkevichWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0009-0003-1467-1606
Nusayhah Hudaa GopeeWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-8507-5682
Alexander PredeusWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-2750-1599
Martin PreteWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Elena WinheimWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-0364-662X
Karl AnnusverDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Agnes ForsthuberDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-6396-0090
Luc FrancisSt John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.
Sophie FrechDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Clarisse GanierInstitut Pasteur, Immunology department, Meta-organism Unit, Paris, France.
Thomas LaytonKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Yingzi LiuDepartment of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8704-4756
Hao YuanDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0080-0812
Beate M LichtenbergerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-6882-0257
Satveer MahilSt John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-4692-3794
Jagdeep NanchahalKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9579-9411
Edel A O'TooleCentre for Cell Biology and Cutaneous Research, The Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.
Maksim V PlikusDepartment of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8845-2559
Yuval RinkevichChinese Institutes for Medical Research, Institute of Regenerative Biology and Medicine, Beijing, China.
Emanuel RognoniCentre for Cell Biology and Cutaneous Research, The Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.
Catherine H SmithSt John's Institute of Dermatology, King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0001-9918-1144
Sarah A TeichmannCambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6294-6366
Maria KasperDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6117-2717
April R FosterWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-5397-4365
Mohammad LotfollahiWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Muzlifah HaniffaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. mh32@sanger.ac.uk.ORCID http://orcid.org/0000-0002-3927-2084
Funding
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1MNIAMS NIH HHS P30 AR075047Wellcome TrustWellcome Trust (Wellcome) 220540/Z/20/A
Abstract
Fibroblasts sculpt the architecture and cellular microenvironments of various tissues. Here we constructed a spatially resolved atlas of human skin fibroblasts from healthy skin and 23 skin diseases, with comparison to 14 cross-tissue diseases. We define six major skin fibroblast subtypes in health and three that are disease-specific. We characterize two fibroblast subtypes further as they are conserved across tissues and are immune-related. The first, F3: fibroblastic reticular cell-like fibroblast (CCL19
Indexed as
FibroblastsSkinSkin DiseasesGenomicsHumansMyofibroblastsSingle-Cell Analysis
Identifiers
What Socratic holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.