Evidence map›Paper›PMID 40993253›Full record

ReviewNature2025

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution.

Arnau Sebé-Pedrós, Amos Tanay, Mara K N Lawniczak, Detlev Arendt, Stein Aerts, John Archibald, Maria Ina Arnone, Mark Blaxter, Phillip Cleves, Susana M Coelho and 33 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Arnau Sebé-PedrósCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. arnau.sebe@crg.eu.ORCID 0000-0002-9896-9746
Amos TanayDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9419-3824
Mara K N LawniczakTree of Life, Wellcome Sanger Institute, Cambridge, UK.ORCID 0000-0002-3006-2080
Detlev ArendtDevelopmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-7833-050X
Stein AertsLaboratory of Computational Biology, VIB Center for AI and Computational Biology, Leuven, Belgium.ORCID 0000-0002-8006-0315
John ArchibaldDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0001-7255-780X
Maria Ina ArnoneStazione Zoologica Anton Dohrn, Napoli, Italy.ORCID 0000-0002-9012-7624
Mark BlaxterTree of Life, Wellcome Sanger Institute, Cambridge, UK.ORCID 0000-0003-2861-949X
Phillip ClevesDepartment of Embryology, Carnegie Science, Baltimore, MD, USA.ORCID 0000-0002-8526-8940
Susana M CoelhoDepartment of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, Tübingen, Germany.ORCID 0000-0002-9171-2550
Mafalda DiasCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-1804-8542
Casey DunnDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.ORCID 0000-0003-0628-5150
Anamaria ElekCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-3938-2494
Jonathan FrazerCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0001-6900-6484
Toni GabaldónICREA, Barcelona, Spain.ORCID 0000-0003-0019-1735
Jesse GillisDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0936-9774
Xavier Grau-BovéCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0003-1978-5824
Roderic GuigóCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-5738-4477
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.ORCID 0000-0002-7634-2854
Jaime Huerta-CepasCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Campus de Montegancedo-UPM, Madrid, Spain.
Manuel IrimiaCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Allon KleinDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8913-7879
Harris LewinGlobal Futures Laboratory, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-1043-7287
Christopher J LoweDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7789-8643
Heather MarlowDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA.
Jacob M MusserDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0000-0002-6163-5152
László G NagyHUN-REN Biological Research Centre Szeged, Szeged, Hungary.
Sebastián R NajleCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Lior PachterDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-9164-6231
Sadye PaezThe Rockefeller University, New York, NY, USA.
Irene PapatheodorouEarlham Institute, Norwich Research Park, Norwich, UK.ORCID 0000-0001-7270-5470
Michael J PassalacquaGenomics Department, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-6344-1175
Nikolaus RajewskyBerlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0002-4785-4332
Seung Y RheePlant Resilience Institute, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-7572-4762
Thomas A RichardsDepartment of Biology, University of Oxford, Oxford, UK.ORCID 0000-0002-9692-0973
Tatjana Sauka-SpenglerStowers Institute for Medical Research, Kansas City, MO, USA.ORCID 0000-0001-9289-0263
Lauren M SaundersCentre for Organismal Studies, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-4377-4252
Eve SeuntjensDepartment of Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-0126-461X
Jordi SolanaLiving Systems Institute, University of Exeter, Exeter, UK.ORCID 0000-0002-6770-3929
Yuyao SongEuropean Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK.ORCID 0000-0001-9738-9726
Ulrich TechnauDepartment of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.ORCID 0000-0003-4472-8258
Bo WangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8880-1432
Biodiversity Cell Atlas meeting participants

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cell types are fundamental functional units that can be traced across the tree of life. Rapid advances in single-cell technologies, coupled with the phylogenetic expansion in genome sequencing, present opportunities for the molecular characterization of cells across a broad range of organisms. Despite these developments, our understanding of eukaryotic cell diversity remains limited and we are far from decoding this diversity from genome sequences. Here we introduce the Biodiversity Cell Atlas initiative, which aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life. This community effort will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species. The Biodiversity Cell Atlas aspires to deepen our understanding of the evolution and diversity of life at the cellular level, encompassing gene regulatory programs, differentiation trajectories, cell-type-specific molecular profiles and inter-organismal interactions.

Indexed as

Atlases as TopicBiodiversityEukaryotaEukaryotic CellsPhylogenySingle-Cell AnalysisAnimalsHumans

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.