SynthesisBritish journal of cancer2026
Factors that influence the uptake of precision-guided treatment recommendations in paediatric cancer: a systematic review.
Synthesis in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions.Children (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite potential benefits, the clinical uptake of precision-guided treatment (PGT) in paediatric oncology remains low. This systematic review aimed to identify factors affecting the adoption of PGT recommendations for children with cancer. Five databases (EMBASE, CINAHL, PubMed, PsycINFO, Scopus) were systematically searched. Qualitative and quantitative studies involving patients aged 0-21 years were included. Two reviewers conducted screening and data extraction. Seventeen studies, all from developed countries, met the criteria: 10 prospective, 4 retrospective, and 3 cross-sectional, involving 3976 patients, 227 healthcare professionals, 189 parents, and 532 community members. Most studies were quantitative, collating factors from clinical records; two qualitative studies used interviews to explore clinician and parent perspectives. Three key domains of factors were identified: (i) decision maker-related characteristics; (ii) decision-specific criteria; and (iii) contextual factors. Common factors included limited drug/clinical trial access, ongoing alternative treatments, high costs, and patient or family preferences. These interlinked factors may affect uptake individually and collectively. To our knowledge, this is the first review to map factors influencing the implementation of PGT in paediatric cancer. Further research is needed to clarify the relative importance of these factors and to better understand oncologists' perspectives when making recommendations in partnership with patients and families. REGISTRATION: PROSPERO database (CRD42023410199).
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.