Key genetic determinants of diabetes remission in patients with obesity following bariatric surgery.

Obesity represents a significant public health challenge on a global scale. Bariatric surgery is an effective intervention for individuals with severe obesity, leading to the amelioration or resolution of numerous obesity-related comorbidities with improved quality of life. Numerous studies have demonstrated that bariatric surgery is more effective than medical weight management interventions for remission of type 2 diabetes (T2D) among patients with obesity; however, there is heterogeneity of response in this regard. In the current analysis, we examined critical differentially expressed genes (DEGs) in patients with obesity and T2D who had remission versus non-remission after bariatric surgery, i.e., responders versus non-responders. We downloaded the gene expression profile GSE271700 from the Gene Expression Omnibus and preprocessed it with GEO2R. 73 differential expressed genes with │ LFC │ > 1 and p value < 0.05 have been recognized in the responder group which were examined in subsequent analyses. SRSF5, MAGOH, LTF, NUP153, CAMP, CEACAM8, and HBD are identified as hub genes using cytoHubba plugin in cytoscape. Moreover, CAMP, CEACAM8, HBD, and LTF were shared between hub genes and the best module (identified using the MCODE plugin). ZBTB33, TAF1, and BCLAF1 were recognized as the most significant transcription factors, and CSNK2A1, CDK1, and MAPK14 were found as the most significant kinases. Moreover, functional analysis showed that DEGs affect mRNA processing and mRNA surveillance pathways. Innate immune response and regulation of cellular response to heat were the best results of biological processes. These results could help to better understand the differences in diabetes remission among patients with obesity.