Evidence map›Paper›PMID 40993455›Full record

ArticleBulletin of experimental biology and medicine2025

An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration.

E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E V EdemskayaV. A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
G G ZasypkinV. A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia. germanzasypkin@yandex.ru.
E Yu PodyachevaV. A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Y G ToropovaV. A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
D V KorolevV. A. Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.

Indexed as

Drug Delivery SystemsNeedlesTransdermal PatchAdministration, CutaneousAnimalsDimethylpolysiloxanesMicroinjectionsPolyestersPolylactic Acid-Polyglycolic Acid CopolymerPrinting, Three-DimensionalbaysilonDimethylpolysiloxanesPolyestersPolylactic Acid-Polyglycolic Acid Copolymerpoly(lactide)biodegradationbiopolymersbrowning of white adipose tissuemicroneedlestransdermal delivery

Identifiers

PMID40993455

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.