SynthesisBMC public health2025
Association of social isolation, loneliness and risk of cardiovascular diseases: Meta-analysis of cohort studies.
Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Social Isolation, Loneliness and Subclinical Atherosclerosis.Current atherosclerosis reports · 2026Review
- Time for a New Whole-Person Care Pathway for Chest Pain Admissions.HCA healthcare journal of medicine · 2026Article
- Associations of Life-Course Social Isolation Trajectories and Depressive Symptoms With the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study.Depression and anxiety · 2026Article
- Article
- Loneliness as a Vital Sign: Toward a Biopsychosocial Reframing of Social Disconnection.Journal of primary care & community healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe association between social isolation, loneliness and risk of cardiovascular diseases (CVD) is not fully understood. This meta-analysis aims to explore social isolation and loneliness whether increases the risk of CVD.
methodsData sources was PubMed and Embase from inception to 10 February 2025. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). Hazard ratios (HR) with 95% confidence intervals (CI) were pooled using a random-effect model, and publication bias was assessed with funnel plots and Egger's test.
resultsThis meta-analysis included six cohort studies with a total of 5,253,128 participants, spanning a follow-up period of 4 to 11.3 years from publications between 1996 and 2022. All studies were of high quality (NOS score ≥ 7). The pooled analysis revealed a heightened risk of CVD among individuals experiencing social isolation or loneliness (HR = 1.17, 95% CI 1.10-1.25, I
conclusionsThe increased risk of CVD among social isolation or loneliness individuals underscore the importance of prioritizing their care in clinical practice and nursing. However, the high heterogeneity in meta-analysis suggests the need for further studies to validate and explore this association thoroughly.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.