Evidence map›Paper›PMID 40993672›Full record

ReviewJournal of translational medicine2025

Human genetic variations conferring resistance to malaria.

Xiaokun Zhang, Jie Wu, Yunxing Peng, Lan Luo, Lu Zhang, Xi Huang, Guoying Chen, Yirong Li, Haoan Yi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaokun Zhang *Functional Laboratory of Experimental Teaching Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.ORCID 0009-0007-8645-9910
Jie Wu *Emergency Medicine Department of First Affiliated Hospital of Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Yunxing PengDepartment of Cell Biology and Medical Genetics, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Lan LuoDepartment of Cell Biology and Medical Genetics, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Lu ZhangDepartment of Cell Biology and Medical Genetics, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Xi HuangFunctional Laboratory of Experimental Teaching Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Guoying ChenDepartment of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China.
Yirong LiFunctional Laboratory of Experimental Teaching Center, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China. liyirongkm@outlook.com.ORCID 0000-0001-9999-1411
Haoan YiDepartment of Cell Biology and Medical Genetics, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, People's Republic of China. yihaoan@outlook.com.

Funding

Programs of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation 202501AY070001-151Yunnan Education Department 2023Y0610Yunnan Education Department 2024J0144Yunnan Education Department 2025J0174Yunnan Education Department 2025Y0363Yunnan Fundamental Research Projects 202401AU070068
6 · The paper itself

Abstract

Malaria remains one of the most significant public health challenges globally, particularly in tropical and subtropical regions. Throughout evolutionary history, malaria-induced natural selection has profoundly influenced human genetic evolution, leading to the emergence of numerous genetic variations that confer resistance to the disease. These adaptations highlight the complicated interplay between pathogens and human genetics. This review focuses on key genetic variations associated with malaria resistance, including hemoglobinopathies (such as sickle cell trait and thalassemia), glucose-6-phosphate dehydrogenase deficiency, blood group polymorphisms and genetic variants related to inflammation and immune regulation. The prevalence of these genetic adaptations varies widely across different geographic regions, reflecting the historical burden of malaria in those areas. Despite significant advancements in genetic research, the precise mechanisms by which these mutations confer protection against malaria remain incompletely understood. Furthermore, the interactions between these genetic factors and environmental influences add to another layer of complexity. A comprehensive understanding of these genetic variations and their functional implications is crucial for advancing malaria epidemiology, improving diagnostic tools, and developing targeted prevention and control strategies, ultimately contributing to global efforts to eradicate malaria.

Indexed as

Disease ResistanceGenetic Predisposition to DiseaseGenetic VariationMalariaHumansEvolutionaryG6PD deficiencyGenetic variationsHemoglobinopathyMalaria resistanceThalassemia

Identifiers

PMID40993672
PMCPMC12462182

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.