ArticleMycoses2025
CT Findings for Differentiating Pulmonary Mucormycosis From Invasive Pulmonary Aspergillosis, Prior to Invasive Procedure Such as a Biopsy or Surgery: A 22-Year Single-Center Experience.
Article in Mycoses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- CT manifestations of pulmonary mucormycosis: Influence of risk factor, symptom duration, and glycemic control.Lung India : official organ of Indian Chest Society · 2026Article
- Pulmonary mucormycosis: Imaging findings and implications.Lung India : official organ of Indian Chest Society · 2026Article
- Advances in the Diagnosis of Invasive Pulmonary Mold Infections: Focus on Diagnostic Performance and Cost-Effectiveness of Diagnostic Tests.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- Pulmonary Aspergillosis Developing After the First Chemotherapy Session in a 15-Year-Old Boy: A Case Report.International medical case reports journal · 2026Article
- Invasive Pulmonary Aspergillosis in Non-Neutropenic Patients: An Evolving Clinical Paradigm.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Epidemiological shifts and advances in research on early diagnosis of invasive fungal infection in critically ill patients.Frontiers in cellular and infection microbiology · 2025Review
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Authors and funding
12 authors.
Funding
Abstract
objectivesComputed tomography (CT) plays a critical role in the early detection and diagnosis of pulmonary invasive mould infection. This study aimed to compare the CT findings of proven invasive pulmonary aspergillosis (IPA) and proven pulmonary mucormycosis (PM) and develop a clinical scoring system based on CT features to differentiate PM from IPA.
methodsThe medical records of the pathology database among adult patients (aged ≥ 18 years) diagnosed with proven IPA or PM between January 2003 and June 2024 were retrospectively reviewed, according to the 2020 European Organisation for Research and Treatment of Cancer criteria. CT scans were reviewed by an experienced radiologist. The primary outcome was CT findings in PM and IPA. We investigated and compared the thoracic CT findings between PM and IPA to identify the predictors of PM compared to IPA prior to invasive diagnostic procedures.
resultsA total of 94 patients were included (60 with IPA and 34 with PM). The most common underlying conditions were malignancy (53.2%) and transplantation (47.9%). In univariable analysis, CT features significantly associated with PM, compared to IPA (p < 0.05), included representative lesion size ≥ 4 cm (odds ratio [OR] 3.61, 95% CI 1.48-8.79), consolidation (OR 5.56, 95% CI 1.52-20.38), halo sign (OR 3.33, 95% CI 1.39-8.02), reverse halo sign (RHS) (OR 6.73, 95% CI 2.39-18.98) and airway-invasive lesion (OR 0.32, 95% CI 0.13-0.78). In multivariate analysis, representative lesion size ≥ 4 cm, RHS, and airway-invasive lesion were identified as independent predictors of PM, compared to IPA. These three factors were incorporated into a point-based scoring system (representative lesion size ≥ 4 cm = 11 points; RHS = score 17 points; airway-invasive lesion = -12 points). A total score of > 8 differentiated PM from IPA with 70.6% sensitivity and 78.3% specificity.
conclusionsCT findings of large consolidative lesions, the presence of a reverse halo sign, and the absence of airway invasion may aid in the early differentiation of PM from IPA.
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