ArticleJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025
Efficacy of a Homemade Very Low Calorie Diet to Achieve Prevention or Remission of Type 2 Diabetes: A Pilot Study.
Article in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionVery low calorie diets have achieved remission of type 2 diabetes in obese individuals and lowered cardiovascular risk. However, there is less evidence for prevention of diabetes with these diets. Oxidative stress is a feature of obesity, diabetes and cardiovascular disease, but it is not clear what impact these diets have on oxidative stress in diabetes or prediabetes. Commercial meal replacement products may be expensive, so in this pilot study, we sought to explore the use of a homemade very low calorie diet to achieve weight loss in obese individuals with prediabetes or early onset type 2 diabetes and the effect on oxidative stress.
methodsIndividuals with a BMI > 35 kg/m
resultsOf 22 individuals enroled at baseline, 16 completed the 12 week diet intervention phase and 12 completed 48 weeks. There were significant falls in weight (p < 0.001), and in waist circumference (p < 0.001) up to 36 weeks with mean weight loss of 15 kg at 48 weeks. HbA1
conclusionWe have demonstrated that an inexpensive homemade very low calorie meal replacement as a weight loss tool has high levels of acceptability in addition to health and quality of life benefits in type 2 or prediabetes. The effect of very low calorie diets on inflammation and oxidative stress require further exploration.
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