Evidence map›Paper›PMID 40994452›Full record

ArticleFood science & nutrition2025

Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota.

Lin Yang, Hua Ni, Xiaogang Gou, Bingqian Zhong, Keyi Wen, Yingying Zhang, Shicui Zhang, Yutao Wang

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A Review on the Molecular Dynamics of EnterotypeInternational journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin YangKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.ORCID https://orcid.org/0009-0001-8878-1539
Hua NiKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.
Xiaogang GouXinjiang Yukunlun Natural Food Engineering Co., Ltd. Kashi China.
Bingqian ZhongKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.
Keyi WenKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.
Yingying ZhangKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.
Shicui ZhangKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.
Yutao WangKey Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University Kashi China.ORCID https://orcid.org/0000-0003-0580-5820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donkey milk (DM) demonstrates promising bioactive properties, including anti-inflammatory and microbiota-modulating effects with therapeutic potential for ulcerative colitis (UC)-though mechanistic research remains limited. To bridge this research gap, a standardized DSS-induced murine UC model was established. Results indicated that daily DM administration markedly attenuated clinical manifestations of UC, such as reduced body weight, intestinal mucosal injury, and increased Disease Activity Index (DAI). Mechanistically, DM enhanced gut barrier integrity through transcriptional upregulation of key genes (

Indexed as

donkey milkgut microbiotaintestinal barrier functionTLR4/MyD88/NF‐κB signaling pathwayulcerative colitis

Identifiers

PMID40994452
PMCPMC12454914

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.