ReviewInternational journal of ophthalmology2025
Systematic review of retinal toxicity after injection of cefuroxime during cataract surgery.
Review in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Current landscape of drug induced retinal vasculitis.Journal of ophthalmic inflammation and infection · 2026Review
- Layer-Specific Retinal Perfusion as a Personalized Biomarker: Evaluating the Subclinical Microanatomical Effects of Intracameral Cefuroxime After Routine Cataract Surgery.Journal of personalized medicine · 2026Article
- Suspected Cefuroxime-Induced Cystoid Macular Edema Following Non-Toric Implantable Collamer Lens Implantation: A Case Report.International medical case reports journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review is to elucidate the retinal toxicity following intraocular injections of cefuroxime, including possible risk factors, clinical manifestations, visual prognosis and treatment. Refereed publications were retrieved from PubMed, the Cochrane Library, and EMBASE databases, using the search terms cefuroxime, retina, macular edema, serous retinal detachment, toxic, cataract surgery. The screening was not limited by publication date, country or study type. We screened out 51 articles out of which 32 met the inclusion criteria for this systematic review. Data regarding sample size calculation reporting and trial characteristics were extracted for each trial. Retinal toxicity can be caused by both high and standard doses of cefuroxime injections in different ethnic groups, with risk factors including overdose, blood-retinal barrier disruption, anterior and posterior chamber connection. The typical clinical manifestations of retinal toxicity are cystoid macular edema and extensive serous retinal detachment, mainly involving the outer nuclear and outer plexiform layers, with a good prognosis for visual acuity in most cases, but in a small number of cases, the prognosis is not satisfactory. In conclusion, though the current use of intracameral injection antibiotics in cataract surgery is gradually increasing, the potential risks should not be ignored. Unexplained poor vision on the first day after cataract surgery can be supplemented with macular optical coherence tomography to rule out cefuroxime-related retinal toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.