ReviewFrontiers in medicine2025
The relationship between orthostatic hypotension and cognitive impairment in Parkinson's disease: a systematic review and meta-analysis.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Orthostatic hypotension (OH) and cognitive impairment are prevalent non-motor symptoms in Parkinson's disease (PD). Although numerous epidemiological studies have explored the association between OH and cognitive impairment, the findings remain controversial. This study aims to systematically evaluate the relationship between OH and cognitive function in patients with PD and to investigate the impact of OH on different cognitive domains. Methods: Databases, including the Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, SinoMed, VIP (Database of Chinese Scientific and Technical Periodicals), PubMed, Embase, Cochrane Library, Web of Science, ProQuest, Scopus, and Ovid, were searched for eligible publications from their inception to July 2025. After literature screening and quality evaluation based on inclusion and exclusion criteria, meta-analysis, heterogeneity testing, sensitivity analysis, and subgroup analysis were conducted using Review Manager 5.4 software. Publication bias analysis was assessed using Stata software. Results: Thirteen studies with a total of 1,417 participants were ultimately included, comprising 552 Parkinson's patients with OH (PD-OH group) and 865 Parkinson's patients without OH (PD-NOH group). Compared to the PD-NOH group, the global cognitive score of the PD-OH group was significantly lower [SMD = -0.62, 95% Conclusion: This meta-analysis indicates that cognitive function decline in PD patients is associated with OH. Patients with OH have lower global cognitive scores compared to those without OH, particularly demonstrating significant deficits in executive, verbal, and visuospatial functions, especially in those with a long disease duration. Clinicians should be vigilant about these potential cognitive deficits and consider comprehensive cognitive assessments and targeted interventions for PD patients experiencing OH.
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