Evidence map›Paper›PMID 40995120›Full record

ArticleiScience2025

Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to spindle dynamics.

Polina Litvak, Nolan D Hartley, Ryan Kast, Guoping Feng, Zhanyan Fu, Alexis Arnaudon, Sean L Hill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Polina LitvakBlue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Nolan D HartleyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ryan KastStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Guoping FengStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zhanyan FuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alexis ArnaudonBlue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Sean L HillBlue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.

Funding

Characterization of structure-function relationships in distinct thalamic reticular nucleus networksR01MH127085 · NIMH · BROAD INSTITUTE, INC. · PI FU, ZHANYAN · 2021 to 2025
$2.0M
NIMH NIH HHS R01 MH127085
6 · The paper itself

Abstract

Burst firing in thalamic reticular neurons is key to sleep rhythms and is linked to neurodevelopmental disorders. Several models of reticular neurons are currently available; however, a biophysically detailed model reproducing experimental burst firing heterogeneity is lacking. We addressed this by combining patch-clamp electrophysiology of fluorescently tagged Spp1+ and Ecel1+ neurons with a previously established statistical framework to differentiate cell types. We developed a population of biophysically detailed thalamic reticular models capturing diverse firing properties, particularly varied rebound bursting. These models incorporate key ion channels, such as T-type Ca

Indexed as

Cellular neuroscienceComputational bioinformaticsSystems neuroscience

Identifiers

PMID40995120
PMCPMC12454877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.