Evidence map›Paper›PMID 40995122›Full record

ArticleiScience2025

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade.

Michael Haffner, Andreas M Enkerlin, Oliver Mantovani, Philipp Spät, Boris Maček, Martin Hagemann, Karl Forchhammer, Khaled A Selim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Functional and structural insights into cyanobacterial COThe Plant journal : for cell and molecular biology · 2026
    Review
  2. Article
  3. ComFB, a widespread family of c-di-NMP receptor proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. ComFB, a new widespread family of c-di-NMP receptor proteins.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael HaffnerInterfaculty Institute for Microbiology and Infection Medicine, Organismic Interactions Department, Tübingen University, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Andreas M EnkerlinMicrobial Biochemistry Group, Institute of Phototrophic Microbiology, Heinrich-Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Oliver MantovaniPlant Physiology Department, Institute of Biological Sciences, Rostock University, Rostock, Germany.
Philipp SpätInterfaculty Institute for Microbiology and Infection Medicine, Organismic Interactions Department, Tübingen University, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Boris MačekQuantitative Proteomics, Interfaculty Institute for Cell Biology (IFIZ), 72076 Tübingen, Germany.
Martin HagemannPlant Physiology Department, Institute of Biological Sciences, Rostock University, Rostock, Germany.
Karl ForchhammerInterfaculty Institute for Microbiology and Infection Medicine, Organismic Interactions Department, Tübingen University, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Khaled A SelimInterfaculty Institute for Microbiology and Infection Medicine, Organismic Interactions Department, Tübingen University, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The photoautotrophic lifestyle of cyanobacteria has to cope with the successive diurnal changes. We previously highlighted a unique function of the carbon control protein, SbtB, and its effector molecule c-di-AMP, for nighttime survival through the regulation of glycogen anabolism. However, the extent to which c-di-AMP and SbtB impact the cellular metabolism for day-night survivability remained elusive. To gain a better understanding, we compared the metabolomic and proteomic landscapes of Δ

Indexed as

BiochemistryBiological sciencesCarbon/Nitrogen metabolismc-di-AMP signalingCyanobacteriaCyanophycinMicrobiologyPhotosynthesisPII-like protein SbtBReactive oxygen species (ROS)Redox imbalance

Identifiers

PMID40995122
PMCPMC12454622

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.