SynthesisFrontiers in nutrition2025
Research status and development trends of probiotics in clinical applications.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, the potential role of probiotics in modulating gut microbiota, enhancing immune function and improving metabolic diseases has become a highly field in biomedical and clinical research. The rapid increase in global probiotic clinical trials necessitates a systematic evaluation of current research status, developmental trends, and collaborative networks in this field. Purpose: This study employs bibliometric analysis to comprehensively evaluate research progress and hotspots in clinical applications of probiotics. Method: A systematic search was performed in the Web of Science database to collect articles and reviews regarding the clinical application of probiotics between 2000 and 2025. The retrieved records were analyzed using Microsoft Office Excel, Cite Space and VOS viewers. Result: During the period from 2000 to 2025, we retrieved a total of 3,674 papers related to the clinical application of probiotics, and the number of papers is showing a continuous growth trend. The research was mainly focused on North America, Western Europe, and East Asia, with the United States leading the way with 714 papers, high impact (H-index 107, total citations 44,833), and top institutions (Harvard Univ). Nutrition and microbiology are the main academic fields. The current research hotspots and development directions focus on the application of probiotics in diseases such as "inflammation", "obesity", "insulin resistance", "depression", "hyperlipidemia", and "cancer". Conclusion: This study represents the first application of bibliometric methods to systematically visualize and analyze research progress in the field of probiotic clinical applications, identifying key research trends and frontiers. The findings offer valuable insights for researchers at various career stages, particularly those new to the field, enabling them to identify critical developments and serving as a foundational reference for future clinical applications of probiotics.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.