ArticleCureus2025
Association Between Vitamin D Supplementation and Urolithiasis Recurrence Outcomes in Known Stone Formers: A Retrospective Cohort Study With Dose-Response Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Vitamin D supplementation is widely prescribed to correct vitamin D deficiency, but its impact on urinary stone recurrence in patients with a history of urolithiasis (stone formers) remains uncertain. Methods We conducted this retrospective cohort study at King Khalid University Hospital, Riyadh, Saudi Arabia. A total of 353 adult stone formers were categorized as non-supplemented (n = 235) or supplemented (n = 118), with stratification by dose (≤800 IU daily, 10,000 IU weekly, and 50,000 IU weekly). The primary outcome was the recurrence of urolithiasis. Secondary outcomes included time-to-recurrence and dose-response. Statistical methods included chi-square testing, Kaplan-Meier analysis, subgroup comparison, and multivariable logistic regression. Clinical and laboratory data were extracted from electronic medical records using a standardized data collection form. Results The mean age of patients was 45.5 ± 14.3 years, with males comprising 68.3% of the cohort. Recurrence occurred in 32.8% of non-supplemented and 45.8% of supplemented patients (absolute risk increase = 13.0%). Multivariable analysis showed higher odds of recurrence with supplementation (adjusted OR = 1.65, 95% CI: 1.01-2.71; p = 0.047). Recurrence rates differed significantly by dose category (p = 0.049), with the highest in the 50,000 IU group. Kaplan-Meier analysis showed no significant difference in time-to-recurrence (p = 0.071). Conclusions In this retrospective cohort of known stone formers, vitamin D supplementation, particularly at higher doses, was associated with a greater risk of recurrence. These findings support the possible need for a more individualized, dose-conscious approach to supplementation in stone-prone patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.