ArticleTaiwan journal of ophthalmology
Excessive corneal endothelial single-cell loss following endothelial injuries.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
purposeThe purpose of this study was to investigate corneal endothelial changes following common clinical endothelial injury scenarios in order to uncover mechanisms underlying unexplained chronic corneal endothelial wound healing. MATERIALS AND
methodsThis cross-sectional study included patients with endothelial injuries from three common scenarios: postcataract surgery, corneal dystrophies, and penetrating injuries. Noncontact specular microscopy was used to capture images from five distinct corneal regions. Endothelial cell density (ECD), coefficient of variation (CV), and percentage of hexagonal cells (HEX) were assessed. All endothelial photographs were also reviewed. Statistical analysis was performed to compare injured and noninjured eyes.
resultsSeventy-seven patients were enrolled, with a mean age of 64 years (48 females, 29 males). The mean central ECD was 2138.91 ± 869.34 cells/mm
conclusionWe identified accelerated stochastic single-cell loss in the corneal endothelium following primary injuries, persisting well beyond the expected wound healing period, a phenomenon that has not been previously highlighted. This finding offers a potential explanation for the chronic endothelial cell loss following a primary injury.
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