ArticleRSC advances2025
Long-acting injectable nanoemulsion for anti-inflammatory therapy: luteolin and resveratrol-loaded CMC formulation regulates TH1/TH2 homeostasis in ovalbumin-induced allergic rhinitis in mice models.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic rhinitis (AR) continues to be a substantial global health concern, requiring the development of effective treatment methods. With an aim of enhancing medicine administration for the treatment of allergic rhinitis, the present work investigates the synthesis and characterization of a nanoemulsion consisting of luteolin (LTN) and resveratrol (RSV) encapsulated in carboxymethyl chitosan (CMC). Unlike traditional oral drugs, this formulation, upon nasal administration, avoids first-pass metabolism and achieves faster and stronger action. At various feed concentrations, LTN's and RSV's loading capacity was assessed to show optimal absorbance, mass of drug loading, and encapsulating efficiency. By means of their zeta potentials, particle size measurements indicated hydrated particle diameters of 215.3 ± 0.1 nm for LTN and 123.63 ± 0.1 nm for RSV, indicating appropriate stability. Functional groups and crystallinity in the formulations were confirmed by FTIR spectroscopy and X-ray diffraction. TEM and SEM morphological studies revealed spherical nanoemulsion droplets showing minimal aggregation. The highest encapsulation efficiencies were LTN at 96.75% and RSV at 97%.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.