ArticleNeurophotonics2025
Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain.The European journal of neuroscience · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Current preclinical evaluation of Alzheimer's disease pathology in mouse models relies on post-mortem analyses, which hinders the development and optimization of therapeutic approaches. Although Aim: We aim to develop an optical approach to address this challenge. Approach: We used flat and tapered optical fibers in an Alzheimer's mouse model. Results: We first confirmed that conventional flat fiber-based photometry can detect amyloid plaque signals across multiple brain regions under anesthesia after injecting a blood-brain-barrier-permeable tracer, Methoxy-X04. The depth profile of Conclusions: Our approach expands the capabilities of fiber photometry to monitor molecular pathologies, such as amyloid plaques, even in a freely behaving condition.
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Registered trials
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