Evidence map›Paper›PMID 40995486›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution.

Nian Liu, Guangming Li, Guohuan Zhang, Yu Li, Tian-Qing Meng, Cheng-Liang Xiong, An Pan, Hua Guo, Yingying Li, Lihong Liu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nian LiuSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Guangming LiDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Guohuan ZhangState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.
Yu LiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.
Tian-Qing MengHubei Province Human Sperm Bank, Wuhan 430030, China.
Cheng-Liang XiongHubei Province Human Sperm Bank, Wuhan 430030, China.
An PanDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hua GuoSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-0329-0088
Yingying LiSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Lihong LiuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.ORCID https://orcid.org/0000-0003-2039-0889
Bin HeSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-7071-7563
Yongguang YinSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-7287-8598
Jianbo ShiSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0003-2637-1929
Yong LiangInstitute of Environment and Health, Jianghan University, Wuhan 430056, China.ORCID https://orcid.org/0000-0003-2212-6694
Yi-Xin WangDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-4324-2408
Ligang HuSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-6213-4720
Guibin JiangSchool of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.ORCID https://orcid.org/0000-0002-6335-3917

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune modulation is crucial for male reproduction and fertility. Metals and metalloids (metals) have been extensively studied for their immunomodulatory effects. Whether metal exposure affects semen quality through immune modulation is unclear. In the present study, we explored the associations between exogenous metals within immune cells, immune cell proportions, and semen quality among 84 healthy men who repeatedly provided 266 semen samples over 90 days. We employed mass cytometry (CyTOF) technology to identify immune cells in semen and measured exogenous metals in these cells at the single-cell resolution. After adjusting for potential confounders, most detected metals in immune cells were inversely associated with the proportion of immune cells in semen samples (all

Indexed as

exogenous metalsimmune cellindirect effectssemen qualitysingle-cell

Identifiers

PMID40995486
PMCPMC12455338

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.