ArticleFrontiers in endocrinology2025
The relationship between novel inflammatory markers SII, SIRI, MHR, UHR and insulin resistance in patients with type 2 diabetes: based on a retrospective analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Diagnostic Accuracy of Inflammatory Biomarkers in Differentiating Acute Appendicitis From Other Acute Abdomen and Predicting Disease Severity: A Prospective Comparative Cross-Sectional Study.Health science reports · 2026Article
- Biologic therapy in geriatric psoriasis: 6-month real-world data on PASI, inflammatory indices, and hepatitis B/tuberculosis safety.Biomolecules & biomedicine · 2026Article
- Investigation of the Relationship Between Glycemic Control and Inflammation-Nutrition Indices in Older Adults with Type 2 Diabetes.Medicina (Kaunas, Lithuania) · 2026Article
- Associations of Inflammatory Prognosis Index With All-Cause and Cardiovascular Mortality Among Individuals With Diabetes and Prediabetes: A Retrospective Cohort Study.Mediators of inflammation · 2026Article
- Peripheral Immune Reprogramming Characterizes a Low C-Peptide Subgroup of Type 2 Diabetes: Transcriptomic Profiling of Peripheral Blood Mononuclear Cells and Systemic Inflammation.Journal of inflammation research · 2026Article
- Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis.Frontiers in endocrinology · 2026Article
- Inflammation Promotes Insulin Resistance: Analysis Based on Inflammation Indices Obtained from the Complete Blood Count.Journal of inflammation research · 2025Article
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4 authors.
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Abstract
Objective: This study aims to investigate the relationship between newly identified inflammatory indicators and IR in patients with T2DM, thereby providing a reference basis for the early clinical prevention, diagnosis, and treatment of IR in patients with T2DM. Methods: A total of 779 patients with T2DM admitted to the Endocrinology Department of our hospital from January 2022 to December 2024 were included in the observation group. Five hundred healthy individuals who underwent physical examinations during the same period were randomly selected as the control group. Patients in the observation group were divided into the IS group, the EIR group, and the SIR according to the HOMA-IR level. Analyze the relationship between the four indicators and IR in patients with T2DM, and observe whether they are independent risk factors for IR in T2DM patients, as well as analyze their clinical utility. Results: Compared with the control group, the levels of inflammatory indicators SII, SIRI, MHR and UHR in the observation group were significantly increased. The levels of SII, SIRI, MHR and UHR in the EIR group and the SIR Group were significantly higher than those in the IS group. Moreover, with the increase in HOMA-IR score, all four inflammatory indicators showed an upward trend. The results of Spearman's rank correlation analysis showed that all four indicators were positively correlated with IR in patients with T2DM. Multivariate ordered logistic regression analysis showed that all four indicators were independent risk factors for IR in patients with T2DM. The ROC results indicated that SII, SIRI, MHR and UHR could serve as potential discriminatory ability indicators for evaluating the degree of IR in patients with T2DM. Conclusion: The levels of SIRI, SII, UHR and MHR in patients with T2DM increase and are positively correlated with IR. They are independent risk factors for IR in patients with T2DM and have clinical utility to a certain extent. They can provide a reference basis for the early clinical prevention, diagnosis and treatment of IR in patients with T2DM.
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