Evidence map›Paper›PMID 40995682›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2

Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shuqi WeiDepartment of Urology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518100, China.ORCID https://orcid.org/0009-0007-6994-8667
Diwen ShouDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Siyuan HuangDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China.
Yingsi WangCenter for Cancer and Immunology Research, State Key Laboratory of Respiratory Disease, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, 510182, China.
Quanzhen LiuGuangzhou Medical University, Guangzhou, Guangdong, 510030, China.
Jinfa LiuDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Xiaoyu LvDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yuyi ZengCenter for Cancer and Immunology Research, State Key Laboratory of Respiratory Disease, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, 510182, China.
Liting WeiCollege of Intelligent Medicine and Biotechnology, Lingui Campus, Guilin Medical University, Guilin, 541199, China.
Han LinGuangzhou Medical University, Guangzhou, Guangdong, 510030, China.
Jiechuan ChenGuangzhou Medical University, Guangzhou, Guangdong, 510030, China.
Yangxiao ChenCenter for Cancer and Immunology Research, State Key Laboratory of Respiratory Disease, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, 510182, China.
Haoyu ZhongGuangzhou Medical University, Guangzhou, Guangdong, 510030, China.
Yanqing ZhouThe Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518100, China.
Wen MaClinical Laboratory, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518100, China.
Li WangSouthern Medical University Affiliated Longhua People's Hospital, Nephrology department, Shenzhen, Guangdong, 518000, China.
Guojun QianKey Laboratory of Anesthesiology, Shanghai Jiao Tong University, Ministry of Education, Ren Ji Hospital, Shanghai, 200127, China.
Jing GuoCenter of oncology, Heyou Hospital, Shunde District, Foshan City, Guangdong, 528000, China.
Donglin SunDepartment of Urology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518100, China.ORCID https://orcid.org/0009-0005-3723-370X

Funding

Guangdong Provincial Medical Science and Technology Research Fund Project A2024317National Natural Science Foundation of China 82400789Research Foundation of Shenzhen Hospital of Southern Medical University 23H3AGZR02The Shenzhen Science and Technology Innovation Committee JCYJ20230807142204008
6 · The paper itself

Abstract

Renal fibrosis is a critical pathological hallmark of chronic kidney disease. Although nonalcoholic fatty liver disease (NAFLD) has been implicated in kidney disease progression, its specific role and underlying mechanisms in renal fibrosis remain poorly understood. This study aims to investigate these mechanisms by establishing a mouse model of renal fibrosis through unilateral ureteral obstruction (UUO) combined with a high-fat diet-induced NAFLD. Single-cell RNA sequencing, untargeted metabolomics, flow cytometry, and immunofluorescence are performed, along with in vitro experiments involving primary renal macrophages and coculture models. It is demonstrated that NAFLD exacerbates renal fibrosis, as HFD-induced hepatocytes release significant levels of ANGPTL8, which activates renal CCR2

Indexed as

Angiopoietin-like ProteinsKidneyMacrophagesNon-alcoholic Fatty Liver DiseasePeptide HormonesReceptors, CCR2Angiopoietin-Like Protein 8AnimalsDiet, High-FatDisease Models, AnimalFibrosisMaleMiceMice, Inbred C57BLReceptors, ImmunologicAngiopoietin-Like Protein 8Angiopoietin-like ProteinsANGPTL8 protein, mouseCcr2 protein, mousePeptide HormonesReceptors, CCR2Receptors, ImmunologicALOX5APANGPTL8macrophagesnonalcoholic fatty liver diseaserenal fibrosis

Identifiers

PMID40995682
PMCPMC12697892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.